| Type | Description |
|---|---|
| Definition | ubiquitin specific peptidase 12 |
| Date | Results | Publications |
|---|---|---|
| 2019-03-09 12:51:00 | WDR20 plays a crucial role in as a "targeting subunit" that modulates CRM1-dependent shuttling of the USP12/UAF1/WDR20 complex between the plasma membrane, cytoplasm and nucleus. | 30466959 |
| 2019-03-02 10:34:00 | USP12 deubiquitinates MDM2 and AR, which in turn controls the levels of the TP53 tumour suppressor and AR oncogene in prostate cancer. | 29755129 |
| 2019-01-05 12:06:00 | Findings indicate that deubiquitinase Usp12 (Usp12) overexpression accelerates autophagic flux and induces an approximately sixfold increase in autophagic structures as determined by ultrastructural analyses. | 30266909 |
| 2017-12-23 12:38:00 | Our results highlight the interfaces essential for regulation of USP12 activity and show a conserved second binding of UAF1 which could be important for regulatory functions independent of USP12 activity. | 27650958 |
| 2017-08-26 12:16:00 | UAF1 and WDR20 interact with USP12 at two distinct sites far from its catalytic center, allosterically activating the enzyme. | 27373336 |
| Type | IDs |
|---|---|
| Synonymous | UBH1, USP12L1 |
| Gene |
UniProtKB-ID:
UBP12_HUMAN
UniprotKB:
O75317
UniParc:
UPI0000198DEE
EMBL:
BC026072,
AL158062,
AK289685,
AF022789,
CH471075,
AL355473
Ensembl:
ENSG00000152484
KO:
hsa:219333
|
| Nucleutide sequences |
EMBL-CDS:
BAF82374.1,
AAH26072.1,
EAX08392.1,
AAC23551.1
Ensembl_TRS:
ENST00000282344
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000282344
RefSeq:
XP_011533258.1,
XP_005266339.1,
NP_872294.2,
XP_016875905.1
|
| Others |
UniRef100:
UniRef100_O75317
UniRef90:
UniRef90_O75317
UniRef50:
UniRef50_O75317
UniGene:
Hs.42400
CCDS:
CCDS31952.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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