| Type | Description |
|---|---|
| Definition | transducin-like enhancer of split 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-29 10:18:00 | The authors found that TLE4 physically interacted with Hes1 (hairy and enhancer of split 1) and inhibited expression of IL-6 and IL-12, two key pro-inflammatory cytokines, in a pattern highly similar to inhibitory action of Hes1. | 29869113 |
| 2019-06-22 11:11:00 | These findings indicate that Tle corepressors are differentially partitioned to Runx and Tcf/Lef complexes to instruct CD8(+) lineage choice and cooperatively establish CD8(+) T cell identity, respectively. | 30045946 |
| 2017-06-24 13:00:00 | These results demonstrated that TLE4 might play important regulatory roles in cellular proliferation and EMT process in HCC. | 27297112 |
| 2015-11-14 10:27:00 | Tle4 KO mice are runted, have defects in bone development, bone marrow aplasia. Have leukocytopenia, b-cell lymphoma and reductions in stem cells by 2 weeks. Die by 4 weeks. | 25153823 |
| 2015-02-14 10:10:00 | TLE3/4 activity is essential for early differentiation where it acts to suppress the pluripotency network, allowing for the initiation of lineage specific gene expression programs | 25446531 |
| Type | IDs |
|---|---|
| Synonymous | 5730411M05Rik, AA792082, Bce-1, Bce1, ESTM13, ESTM14, Grg4, X83332, X83333, grg-4 |
| Gene |
UniProtKB-ID:
TLE4_MOUSE,
Q3UY41_MOUSE
UniprotKB:
Q62441,
Q3UY41
UniParc:
UPI000019473D,
UPI00005ABB2E
EMBL:
AF229633,
AK134989,
U61363
Ensembl:
ENSMUSG00000024642
KO:
mmu:21888
|
| Nucleutide sequences |
EMBL-CDS:
AAF43203.1,
AAC97070.1,
BAE22372.1
Ensembl_TRS:
ENSMUST00000052011
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000057527
RefSeq:
XP_006526976.1,
NP_001289880.1,
XP_030106722.1,
NP_001289876.1,
XP_030106723.1,
NP_001289879.1,
XP_006526977.1,
NP_035730.2,
XP_030106724.1
|
| Others |
UniRef100:
UniRef100_Q62441,
UniRef100_Q3UY41
UniRef90:
UniRef90_Q04727
UniRef50:
UniRef50_Q04724
UniGene:
Mm.103638
CCDS:
CCDS50399.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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