| Type | Description |
|---|---|
| Definition | transducin-like enhancer of split 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:22:00 | The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development. | 32601467 |
| 2019-09-14 12:37:00 | TLE3 regulates thermogenic gene expression in beige adipocytes through inhibition of EBF2 transcriptional activity | 31123067 |
| 2019-06-22 11:11:00 | These findings indicate that Tle corepressors are differentially partitioned to Runx and Tcf/Lef complexes to instruct CD8(+) lineage choice and cooperatively establish CD8(+) T cell identity, respectively. | 30045946 |
| 2017-08-26 13:10:00 | Data suggest Tle3 plays role in regulation of MyoD1 function during myogenesis; up-regulation of Tle3 expression suppresses myogenesis; conversely, down-regulation of Tle3 expression promotes myogenesis/cell proliferation; Tle3 interferes with MyoD1 by disrupting association of basic helix-loop-helix domain of MyoD with E proteins. (Tle3 = transducin-like enhancer of split 3; MyoD1 = myogenic differentiation protein 1) | 28607151 |
| 2015-09-12 10:49:00 | Increased adipose tissue (AT) TLE3 in subjects with type 2 diabetes and in AT from high fat diet and PPARgamma knockout mice suggest that TLE3 may play an adaptive regulatory role that improves AT function under decreased PPARgamma expression | 25249007 |
| Type | IDs |
|---|---|
| Synonymous | 2610103N05Rik, ESG, Grg3a, Grg3b, mKIAA1547 |
| Gene |
UniProtKB-ID:
TLE3_MOUSE,
Q80TC1_MOUSE,
F8WIE2_MOUSE,
E0CXS9_MOUSE
UniprotKB:
Q08122,
Q80TC1,
F8WIE2,
E0CXS9
UniParc:
UPI0000F50D2C,
UPI00014BF75F,
UPI00014BF760,
UPI0001DD34FA,
UPI00001833AE,
UPI0000004360,
UPI00001BD7E4
EMBL:
X73360,
BC006672,
AC126672,
AK031322,
BC056465,
AK122524
Ensembl:
ENSMUSG00000032280
KO:
mmu:21887
|
| Nucleutide sequences |
EMBL-CDS:
BAC27347.1,
AAH56465.1,
AAH06672.1,
CAA51770.1,
BAC65806.1
Ensembl_TRS:
ENSMUST00000162973,
ENSMUST00000160882,
ENSMUST00000162583,
ENSMUST00000034820,
ENSMUST00000159050
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000124131,
ENSMUSP00000124173,
ENSMUSP00000124977,
ENSMUSP00000034820,
ENSMUSP00000125032
RefSeq:
XP_006511090.1,
XP_017168766.1,
XP_006511093.1,
NP_001077396.1,
XP_017168768.1,
XP_006511092.1,
NP_033415.2,
NP_001077397.1,
XP_006511094.1,
XP_006511089.1,
XP_006511088.1,
XP_036010732.1,
XP_006511091.1,
XP_017168767.1
|
| Others |
UniRef100:
UniRef100_Q08122,
UniRef100_E0CXS9,
UniRef100_F8WIE2
UniRef90:
UniRef90_Q9JIT3,
UniRef90_Q04726
UniRef50:
UniRef50_Q04724,
UniRef50_Q04726
UniGene:
Mm.24255
CCDS:
CCDS52825.1,
CCDS52826.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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