| Type | Description |
|---|---|
| Definition | transducin-like enhancer of split 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-02 13:23:00 | Tle1 attenuates hepatic ischemia/reperfusion injury by suppressing NOD2/NF-kappaB signaling. | 32114961 |
| 2019-06-22 11:11:00 | These findings indicate that Tle corepressors are differentially partitioned to Runx and Tcf/Lef complexes to instruct CD8(+) lineage choice and cooperatively establish CD8(+) T cell identity, respectively. | 30045946 |
| 2018-07-14 10:05:00 | Demethylation of TLE1 promoter region activates the self-expression in diabetic mice intestinal epithelium cells (IECs). Subsequently, TLE1, through the transcriptional suppression on expression of Hes1, contributes to the aberrant differentiation of IECs in DM mice. | 28744818 |
| 2016-08-13 10:12:00 | Data suggest that Tle1 is highly expressed in activated macrophages cultured in vitro; expression of Tle1 is low in resting macrophages and is up-regulated upon macrophage activation (here, stimulated with recombinant human interleukin-4). | 26763127 |
| 2016-07-30 10:09:00 | Loss of Tle1 not only results in increased phosphorylation and activation of proinflammatory NF-kappaB but also results in decreased Hes1 (hairy and enhancer of split-1), a negative regulator of inflammation in macrophages | 26831087 |
| Type | IDs |
|---|---|
| Synonymous | C230057C06Rik, Estm14, Grg-1, Grg1, Tle4l |
| Gene |
UniProtKB-ID:
TLE1_MOUSE,
Q5SQA3_MOUSE,
Q6PFG2_MOUSE,
Q5SQA2_MOUSE,
Q5SQA4_MOUSE
UniprotKB:
Q62440,
Q5SQA3,
Q6PFG2,
Q5SQA2,
Q5SQA4
UniParc:
UPI000002B565,
UPI000002B562,
UPI000002B568,
UPI0000137035,
UPI000002B567,
UPI000047079D,
UPI000047079E,
UPI000002B564,
UPI00001D61E8,
UPI000002B563,
UPI00001957C9,
UPI000002B566
EMBL:
AY155199,
AY155200,
AK052961,
AY155196,
AY155195,
AL773513,
AK076750,
BX640475,
AY155198,
AY155197,
AK046402,
AK082499,
BC057573,
U61362
Ensembl:
ENSMUSG00000008305
KO:
mmu:21885
|
| Nucleutide sequences |
EMBL-CDS:
AAN77516.1,
AAN77518.1,
AAN77514.1,
BAC36464.1,
AAN77517.1,
BAC32708.1,
AAN77515.1,
AAN77519.1,
BAC35221.1,
AAB49934.1,
BAC38509.1,
AAH57573.1
Ensembl_TRS:
ENSMUST00000107337,
ENSMUST00000030095,
ENSMUST00000072695,
ENSMUST00000102848
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000102960,
ENSMUSP00000030095,
ENSMUSP00000072481,
ENSMUSP00000099912
RefSeq:
XP_011248288.1,
NP_001272459.1,
XP_030109262.1,
XP_011248287.2,
XP_011248283.1,
XP_017175598.1,
XP_006537824.1,
XP_030109263.1,
XP_017175601.1,
XP_036019852.1,
XP_017175597.1,
XP_006537821.1,
XP_017175595.1,
XP_011248281.2,
XP_030109261.1,
XP_030109258.1,
NP_001272458.1,
XP_011248284.2,
NP_001272460.1,
XP_036019853.1,
XP_011248280.1,
XP_030109259.1,
XP_017175594.1,
XP_036019849.1,
XP_017175596.1,
XP_006537823.1,
XP_017175593.1,
XP_017175600.1,
NP_001272461.1,
NP_035729.3,
XP_006537829.1,
XP_030109260.1,
XP_036019851.1,
XP_006537822.1,
XP_017175599.1,
XP_036019854.1,
XP_011248282.1
|
| Others |
UniRef100:
UniRef100_Q6PFG2,
UniRef100_Q5SQA4,
UniRef100_Q5SQA2,
UniRef100_Q62440,
UniRef100_Q5SQA3
UniRef90:
UniRef90_Q62440,
UniRef90_W5PRV3
UniRef50:
UniRef50_A0A1D5P5C3,
UniRef50_Q04724
UniGene:
Mm.278444,
Mm.388819,
Mm.399716
CCDS:
CCDS18274.1,
CCDS71407.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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