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21873 Tjp2

21873

Tjp2

tight junction protein 2

protein-coding

Mus musculus

基因描述

Type Description
Definition tight junction protein 2

研究结论

Date Results Publications
2021-04-17 13:14:00 The zonula occludens protein family regulates the hepatic barrier system in the murine liver. 33184034
2019-04-27 10:15:00 Based on results obtained in cultured epithelial cells transfected with ZO-2 mutated at a MET target lysine residue. 30291936
2018-10-20 10:20:00 Podocyte-specific deletion of the ZO-2 gene did not cause overt defects; however, double knockout of ZO-1 and ZO-2 genes accelerated the defects observed in ZO-1 knockout mice. These results suggest that ZO-2 plays supportive roles in the ZO-1-dependent regulation of podocyte filtration barrier. 29845705
2017-11-25 12:39:00 In the present study, we found that the protein level of ZO-2, a scaffolding tight junction protein, decreased in the bladder of OVX mice indicating a possible role in overactive bladder. 28420508
2016-01-16 10:47:00 Expression of Podocalyxin, which positively regulates the formation of microvilli and the apical membrane, is repressed in embryoid bodies lacking both ZO-1 and ZO-2 and this correlates with an aberrant submembranous localization of Ezrin. 24905925

名称对应

Type IDs
Synonymous ZO-2
Gene
UniProtKB-ID: ZO2_MOUSE, A0A3B2WCN9_MOUSE
UniprotKB: Q9Z0U1, A0A3B2WCN9
UniParc: UPI0001548FF7, UPI0000006C1B
EMBL: AC149224, AF113005, BC039924, BC034677, AC107685
Ensembl: ENSMUSG00000024812
KO: mmu:21873
Nucleutide sequences
EMBL-CDS: AAH39924.1, AAH34677.1, AAD19964.1
Ensembl_TRS: ENSMUST00000099558, ENSMUST00000233658, ENSMUST00000233027
Protein sequencees
Ensembl_PRO: ENSMUSP00000156728, ENSMUSP00000097154, ENSMUSP00000156605
RefSeq: NP_001347321.1, NP_001185914.1, NP_001363297.1, XP_017173625.1, XP_006526967.1, NP_001347320.1, XP_006526972.1, XP_030106721.1, NP_035727.2, XP_036017405.1, XP_006526970.1
Others
UniRef100: UniRef100_A0A3B2WCN9, UniRef100_Q9Z0U1
UniRef90: UniRef90_Q9Z0U1
UniRef50: UniRef50_Q9UDY2-2
UniGene: Mm.104744
CCDS: CCDS89365.1

全选

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