| Type | Description |
|---|---|
| Definition | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-23 12:13:00 | Valvular endothelial Tie-1 tyrosine kinase receptor 1Tie1 is differentially expressed in a dynamic pattern during valve remodeling. | 31319059 |
| 2019-07-20 10:15:00 | Tie1 has regulatory functions in angiogenesis and vascular abnormalization as well as metastasis | 29355844 |
| 2018-03-10 12:02:00 | We identified colorectal cancer as a novel Tie1-expressing tumor, with Tie1-positive cells hardly detectable in the normal intestine. Tie1 expression did not influence cancer cell proliferation in regular in vitro cultures, but significantly affected malignant growth of transplanted tumors in vivo. | 28464467 |
| 2016-07-16 10:10:00 | Data support an interactive model of Tie1 and Tie2 function, in which dynamically regulated Tie1 versus Tie2 expression determines the net positive or negative effect of Tie1 on Tie2 signaling. | 26344773 |
| 2015-05-02 10:05:00 | Data indicate that receptor tyrosine kinase Tie1 deletion resulted in lack of lymphatic valves and collecting vessel defects. | 25576926 |
| Type | IDs |
|---|---|
| Synonymous | D430008P04Rik, TIE, tie-1 |
| Gene |
UniProtKB-ID:
TIE1_MOUSE
UniprotKB:
Q06806
UniParc:
UPI00000EB9FE
EMBL:
AK052192,
AL627212,
X80764,
BC046452,
AK052413,
X73960,
S79346,
X71425
Ensembl:
ENSMUSG00000033191
KO:
mmu:21846
|
| Nucleutide sequences |
EMBL-CDS:
AAH46452.2,
BAC34979.1,
BAC34876.1,
CAA50556.1,
CAA52148.1,
CAA56739.1
Ensembl_TRS:
ENSMUST00000047421
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000037129
RefSeq:
NP_035717.2
|
| Others |
UniRef100:
UniRef100_Q06806
UniRef90:
UniRef90_P35590
UniRef50:
UniRef50_P35590
UniGene:
Mm.4345
CCDS:
CCDS18553.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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