| Type | Description |
|---|---|
| Definition | thrombopoietin |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:23:00 | Erythropoietin is a major regulator of thrombopoiesis in thrombopoietin-dependent and -independent contexts. | 32721504 |
| 2019-12-14 12:35:00 | Thpo-regulated mitochondrial activity associated with mitochondrial translocation of phosphorylated at serine 727. | 30428347 |
| 2019-12-07 12:04:00 | Authors demonstrate that thrombopoietin and its receptor MPL are critical for the human JAK2V617F-bearing MK-induced myeloproliferation in mice, both by directly affecting the quantity and quality of MKs and by altering the MK-endothelial interaction and vascular niche function. | 30005133 |
| 2019-10-05 10:46:00 | Study of hepatocarcinogenesis induced by diethylnitrosamine in B6C3F1 mice, the BrafV637E mutation, corresponding to the human BRAFV600E mutation, suggested that the TPO-mediated macroenvironmental changes involving the liver and bone marrow may promote proliferation of the BRAFV600E-mutated hepatocytes, but cause hematological, renal, and pulmonary disorders that lead to death. | 31301081 |
| 2019-05-25 11:43:00 | The number of lung metastases was significantly lower in Tpo(-/-) mice compared to Tpo(+/+) mice. The same was true for the bone-tropic 4T1.2 derivative. | 30043083 |
| Type | IDs |
|---|---|
| Synonymous | Mgdf, Ml, Mpllg, Tpo |
| Gene |
UniProtKB-ID:
TPO_MOUSE,
Q543R9_MOUSE
UniprotKB:
P40226,
Q543R9
UniParc:
UPI000002B5BD,
UPI000000185B
EMBL:
AK047512,
BC003803,
L34169
Ensembl:
ENSMUSG00000022847
KO:
mmu:21832
|
| Nucleutide sequences |
EMBL-CDS:
AAH03803.1,
AAA40436.1,
BAC33078.1
Ensembl_TRS:
ENSMUST00000076422,
ENSMUST00000115437
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000111097,
ENSMUSP00000075756
RefSeq:
XP_017172420.1,
XP_006522050.1,
XP_017172415.1,
NP_001276823.1,
XP_017172422.1,
XP_017172416.1,
NP_001166976.1,
NP_001276825.1,
XP_017172421.1,
XP_017172418.1,
XP_036015764.1,
XP_017172417.1,
XP_017172419.1,
NP_033405.1
|
| Others |
UniRef100:
UniRef100_P40226
UniRef90:
UniRef90_P40226
UniRef50:
UniRef50_P40225
UniGene:
Mm.3943
CCDS:
CCDS37292.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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