| Type | Description |
|---|---|
| Definition | potassium channel, subfamily K, member 13 |
| Date | Results | Publications |
|---|---|---|
| 2019-07-20 13:10:00 | THIK-1 is the main K(+) channel expressed in microglia in situ. THIK-1 is tonically active, and its activity is potentiated by P2Y12 receptors. Microglial immune surveillance and cytokine release require THIK-1 channel activity. | 29290552 |
| 2017-07-01 12:34:00 | Dysregulation of a potassium channel, THIK-1, targeted by caspase-8, accelerates cell shrinkage. | 27566292 |
| 2010-01-21 00:00:00 | THIK-1 and THIK-2 are abundantly expressed in the proximal and distal nephron of the mammalian kidney. | 18209473 |
| Type | IDs |
|---|---|
| Synonymous | BB085247, F730021E22Rik, Gm1570, Gm1685 |
| Gene |
UniProtKB-ID:
KCNKD_MOUSE,
Q3TYG8_MOUSE
UniprotKB:
Q8R1P5,
Q3TYG8
UniParc:
UPI0000025FE7
EMBL:
AK155396,
BC023443,
AK158645
Ensembl:
ENSMUSG00000045404
KO:
mmu:217826
|
| Nucleutide sequences |
EMBL-CDS:
AAH23443.1,
BAE33240.1,
BAE34595.1
Ensembl_TRS:
ENSMUST00000177549,
ENSMUST00000049788,
ENSMUST00000160413
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000136882,
ENSMUSP00000123916,
ENSMUSP00000051846
RefSeq:
NP_666149.1,
NP_001157899.1,
XP_036013234.1,
XP_030102525.1,
NP_001157898.1
|
| Others |
UniRef100:
UniRef100_Q8R1P5
UniRef90:
UniRef90_Q9ERS0
UniRef50:
UniRef50_Q9ERS0
UniGene:
Mm.312335
CCDS:
CCDS26106.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 29290552 |
Neuron Christian Madry , Vasiliki Kyrargyri , I Lorena Arancibia-Cárcamo , Renaud Jolivet , Shinichi Kohsaka , Robert M Bryan , David Attwell |
2018-01-17 | - |
| 27566292 |
Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage. Biochim. Biophys. Acta Kazuhiro Sakamaki , Takahiro M Ishii , Toshiya Sakata , Kiwamu Takemoto , Chiyo Takagi , Ayako Takeuchi , Ryo Morishita , Hirotaka Takahashi , Akira Nozawa , Hajime Shinoda , Kumiko Chiba , Haruyo Sugimoto , Akiko Saito , Shuhei Tamate , Yutaka Satou , Sang-Kee Jung , Satoshi Matsuoka , Koji Koyamada , Tatsuya Sawasaki , Takeharu Nagai , Naoto Ueno |
2016-11-01 | - |
| 24154525 |
Development Jeremy A Miller , Jason Nathanson , Daniel Franjic , Sungbo Shim , Rachel A Dalley , Sheila Shapouri , Kimberly A Smith , Susan M Sunkin , Amy Bernard , Jeffrey L Bennett , Chang-Kyu Lee , Michael J Hawrylycz , Allan R Jones , David G Amaral , Nenad Å estan , Fred H Gage , Ed S Lein |
2013-11-01 |
Rpp25,
Gldc,
Rhoq,
Psat1,
Tm6sf1,
Slc14a1,
Rimklb,
Nusap1,
Mybpc1,
Npy,
Bmp3,
Adgrv1,
Dlx1as,
Acadl,
Laptm4b,
Pawr,
Adra1a,
Alcam,
Aldoc,
Necab2,
Ank1,
Apoe,
Nr2f2,
Aqp4,
Rnd2,
Arnt2,
Bcan,
Bcat1,
Fabp7,
Zfp36l1,
C1qc,
Calb2,
Capn2,
Car2,
Cbln2,
Cbs,
Ccnd2,
Cd24a,
Entpd2,
Cd63,
Cd81,
Cd9,
Cdh11,
Cdh5,
Cit,
Ckb,
Cldn5,
Clu,
Cnp,
Cnr1,
Col19a1,
Col9a3,
Cort,
Cox6a2,
Cplx1,
Hapln1,
Cryab,
Csrp1,
Cst3,
Ctsd,
Ctsl,
Ctss,
Cux2,
Dbi,
Dcx,
Asap1,
Dio2,
Dlx1,
Cdk2ap1,
Ect2,
Egfr,
Eps8,
Erbb4,
Eya4,
Elmo1,
Fasn,
Fgf12,
Fgfr1,
Gaa,
Gabrg3,
Gad1,
Gad2,
Gap43,
Gfap,
Gpr83,
Gja1,
Gjd2,
Glul,
Glrb,
Gnai1,
Gnas,
Got1,
Adgrg1,
Cdca3,
Gria4,
Grik1,
Grpr,
Hbb-b1,
Hbb-b2
|
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 21677750 |
A conditional knockout resource for the genome-wide study of mouse gene function. Nature William C Skarnes , Barry Rosen , Anthony P West , Manousos Koutsourakis , Wendy Bushell , Vivek Iyer , Alejandro O Mujica , Mark Thomas , Jennifer Harrow , Tony Cox , David Jackson , Jessica Severin , Patrick Biggs , Jun Fu , Michael Nefedov , Pieter J de Jong , A Francis Stewart , Allan Bradley |
2011-06-15 | - |
| 19554387 |
Cerebellum Karl Schilling , John Oberdick |
2009-12-01 |
Cdh22,
Nxph4,
Sbk1,
Slc6a5,
Grm2,
Grm3,
Grm5,
Ogt,
Laptm4b,
Asic2,
Ache,
Cygb,
Bcan,
Cacna2d3,
Calb2,
Cdh13,
Cnr1,
Cux1,
Ephb2,
Gad1,
Gad2,
Grm1,
Grm8,
Hcn1,
Elavl2,
Impact,
Kcna2,
Kcnab3,
Kcnma1,
Kit,
Lamb1,
Lhx9,
Stard5,
Ripply3,
Nefm,
Nrxn3,
Nsg1,
Nsg2,
Ntn1,
Pam,
Pax2,
Pcp4,
Penk,
Pfn2,
Prkcd,
Cabp7,
Ptprk,
Pvalb,
Resp18,
Rora,
Sst,
Snca,
Serpini1,
Spock1,
Socs2,
Kcnk13,
Tnr,
Trpc3,
Slc32a1,
Vldlr,
Nrsn2,
Iqsec1,
Slc6a1,
Iqsec3,
Sema4g,
Homer3,
Abat,
Plch1,
Cntn4,
Cabp1,
Snhg11,
Eml5,
Zmat4,
D830030K20Rik,
Lypd6,
Arl4c,
Hapln4,
2900097C17Rik,
Nefh,
Shisa6,
Vgf,
Zwint,
Ahi1,
Rcan2,
Slc12a5,
Dusp10,
Kcng4,
Nos1ap,
Rassf8,
Galnt14,
Tspyl4,
Spock3,
Whrn,
Lrrtm1,
Chst1,
Nrip3,
Trim9,
Dtnbp1,
Slc24a3
|
| 18209473 |
Cell. Physiol. Biochem. Franziska Theilig , Irena Goranova , Jochen R Hirsch , Martin Wieske , Semanur Unsal , Sebastian Bachmann , Rudiger W Veh , Christian Derst |
2008-01-01 | - |
| 16985003 |
Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Physiol. Genomics M D Harrell , S Harbi , J F Hoffman , J Zavadil , W A Coetzee |
2007-02-12 |
Kcnq3,
Scn4a,
Atp2a2,
Cacna1a,
Cacna1b,
Cacna1c,
Cacna1d,
Cacna1e,
Cacna1g,
Cacna1s,
Cacna2d1,
Cacna2d3,
Cacnb1,
Cacnb2,
Cacnb3,
Cacnb4,
Cacng1,
Cacng2,
Clca3a1,
Clcn1,
Clcn2,
Clcn3,
Clcn4,
Clcn5,
Clns1a,
Clcnka,
Kcnn2,
Kcnn3,
Cacng5,
Gja5,
Hcn1,
Hcn2,
Hcn3,
Kcna1,
Kcna2,
Kcna3,
Kcna4,
Kcna5,
Kcna6,
Kcna7,
Kcnab1,
Kcnab2,
Kcnab3,
Kcnb1,
Kcnc1,
Kcnc3,
Kcnd1,
Kcnd2,
Kcne1,
Kcnh1,
Kcnh2,
Kcnh3,
Kcnj10,
Kcnj11,
Kcnj15,
Kcnj16,
Kcnj2,
Kcnj3,
Kcnj4,
Kcnj5,
Kcnj6,
Kcnj8,
Kcnj9,
Kcnk1,
Kcnk2,
Kcnk3,
Kcnk4,
Kcnk5,
Kcnk7,
Kcnma1,
Kcnmb1,
Kcnn4,
Kcnq1,
Kcnq2,
Kcns1,
Kcns2,
Kcnh7,
P2rx1,
P2rx4,
P2rx7,
P2rx6,
Pln,
Kcnh6,
Ryr2,
Scn10a,
Scn1a,
Scn1b,
Scn3a,
Scn5a,
Scn7a,
Scn8a,
Scn9a,
Scnn1a,
Scnn1b,
Scnn1g,
Slc8a1,
Abcc8,
Abcc9,
Kcnk12
|
| 16141073 |
Antisense transcription in the mammalian transcriptome. Science S Katayama , Y Tomaru , T Kasukawa , K Waki , M Nakanishi , M Nakamura , H Nishida , C C Yap , M Suzuki , J Kawai , H Suzuki , P Carninci , Y Hayashizaki , C Wells , M Frith , T Ravasi , K C Pang , J Hallinan , J Mattick , D A Hume , L Lipovich , S Batalov , P G Engström , Y Mizuno , M A Faghihi , A Sandelin , A M Chalk , S Mottagui-Tabar , Z Liang , B Lenhard , C Wahlestedt , RIKEN Genome Exploration Research Group , Genome Science Group (Genome Network Project Core Group) , FANTOM Consortium |
2005-09-02 |
Gm14018,
Gm14964,
F630206G17Rik,
Oog3,
Notumos,
Ldlrap1,
Mdn1,
Pydc3,
9330171B17Rik,
Mfap1b,
Tmsb15b2,
Gm12802,
E430020m11rik,
Gm11335,
Gm15772,
Gm17762,
A930017K11Rik,
LOC100036513,
Gata5os,
Umad1,
Gm16982,
Gm9887,
Gm9872,
LOC100036530,
Gm9934,
Gm9913,
Gm11149,
BC028777,
Gm13999,
LOC100036540,
Gm9744,
Gm9983,
D630002J18Rik,
Gm16525,
Gm11696,
Dnajc3,
9430060I03Rik,
Gm12359,
4921516A02Rik,
Fam129c,
Gm10589,
Rsph3b,
Rnaset2a,
5430403G19Rik,
D030047H15Rik,
Gm13274,
B930046K06Rik,
Gm10862,
Gm10792,
Gm10802,
Gm10532,
G730003C15Rik,
Runx2os1,
Gm15612,
Gm10856,
Gm10857,
Gm10685,
Gm10803,
Gm10723,
F630028O10Rik,
Gm10836,
Gm10405,
Gm10513,
Gm10609,
F630201L12Rik,
4932427H20Rik,
Zfp389,
Gm10763,
Gm10062,
Gm10714,
Gm10531,
Gm10876,
Gm10750,
Gm10433,
Gm10837,
Gm10647,
Gm10648,
Gm10650,
Gm10610,
F830115B05Rik,
Gm10473,
Gm10614,
Gm10286,
G730046D07Rik,
Gm10287,
Gm10785,
Gm10183,
Gm10512,
1700061E17Rik,
Gm44113,
Gm10579,
Gm10741,
Gm10827,
Gm10522,
Gm10536,
Gm15998,
Faddos,
D130050E23Rik,
Gm10735
|
| 16141072 |
The transcriptional landscape of the mammalian genome. Science P Carninci , T Kasukawa , S Katayama , J Gough , M C Frith , N Maeda , R Oyama , T Ravasi , B Lenhard , C Wells , R Kodzius , K Shimokawa , V B Bajic , S E Brenner , S Batalov , A R R Forrest , M Zavolan , M J Davis , L G Wilming , V Aidinis , J E Allen , A Ambesi-Impiombato , R Apweiler , R N Aturaliya , T L Bailey , M Bansal , L Baxter , K W Beisel , T Bersano , H Bono , A M Chalk , K P Chiu , V Choudhary , A Christoffels , D R Clutterbuck , M L Crowe , E Dalla , B P Dalrymple , B de Bono , G Della Gatta , D di Bernardo , T Down , P Engstrom , M Fagiolini , G Faulkner , C F Fletcher , T Fukushima , M Furuno , S Futaki , M Gariboldi , P Georgii-Hemming , T R Gingeras , T Gojobori , R E Green , S Gustincich , M Harbers , Y Hayashi , T K Hensch , N Hirokawa , D Hill , L Huminiecki , M Iacono , K Ikeo , A Iwama , T Ishikawa , M Jakt , A Kanapin , M Katoh , Y Kawasawa , J Kelso , H Kitamura , H Kitano , G Kollias , S P T Krishnan , A Kruger , S K Kummerfeld , I V Kurochkin , L F Lareau , D Lazarevic , L Lipovich , J Liu , S Liuni , S McWilliam , M Madan Babu , M Madera , L Marchionni , H Matsuda , S Matsuzawa , H Miki , F Mignone , S Miyake , K Morris , S Mottagui-Tabar , N Mulder , N Nakano , H Nakauchi , P Ng , R Nilsson , S Nishiguchi , S Nishikawa , F Nori , O Ohara , Y Okazaki , V Orlando , K C Pang , W J Pavan , G Pavesi , G Pesole , N Petrovsky , S Piazza , J Reed , J F Reid , B Z Ring , M Ringwald , B Rost , Y Ruan , S L Salzberg , A Sandelin , C Schneider , C Schönbach , K Sekiguchi , C A M Semple , S Seno , L Sessa , Y Sheng , Y Shibata , H Shimada , K Shimada , D Silva , B Sinclair , S Sperling , E Stupka , K Sugiura , R Sultana , Y Takenaka , K Taki , K Tammoja , S L Tan , S Tang , M S Taylor , J Tegner , S A Teichmann , H R Ueda , E van Nimwegen , R Verardo , C L Wei , K Yagi , H Yamanishi , E Zabarovsky , S Zhu , A Zimmer , W Hide , C Bult , S M Grimmond , R D Teasdale , E T Liu , V Brusic , J Quackenbush , C Wahlestedt , J S Mattick , D A Hume , C Kai , D Sasaki , Y Tomaru , S Fukuda , M Kanamori-Katayama , M Suzuki , J Aoki , T Arakawa , J Iida , K Imamura , M Itoh , T Kato , H Kawaji , N Kawagashira , T Kawashima , M Kojima , S Kondo , H Konno , K Nakano , N Ninomiya , T Nishio , M Okada , C Plessy , K Shibata , T Shiraki , S Suzuki , M Tagami , K Waki , A Watahiki , Y Okamura-Oho , H Suzuki , J Kawai , Y Hayashizaki , FANTOM Consortium , RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) |
2005-09-02 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
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| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
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目前还没有研究热点人员