| Type | Description |
|---|---|
| Definition | mutL homolog 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-09-26 13:08:00 | A point mutation in the nuclease domain of MLH3 eliminates repeat expansions in a mouse stem cell model of the Fragile X-related disorders. | 32619224 |
| 2020-02-29 11:30:00 | We identify, de novo, DNA sequence motifs associated with individual components that define temporally varying modes of gene expression control. Analysis of SDA components also led us to identify a rare population of macrophages within the seminiferous tubules of Mlh3(-/-) and Hormad1(-/-) mice, an area typically associated with immune privilege | 31237565 |
| 2019-11-09 11:37:00 | Double mutant mice homozygous for the Mlh3DN/DN and Mus81-/- mutations show losses in chiasmata close to those observed in Mlh3-/- males, indicating that the MUS81-EME1-regulated crossover pathway can only partially account for the increased residual chiasmata in Mlh3DN/DN spermatocytes | 31170160 |
| 2015-02-21 12:03:00 | these data identify Mlh1 and Mlh3 as novel critical genetic modifiers of HTT CAG instability, point to Mlh1 genetic variation as the likely source of the instability difference in B6 and 129 strains | 24204323 |
| 2010-01-21 00:00:00 | Associated with MSH4 in mammalian meiotic cells, supporting the possibility that MLH3 plays a role in meiotic recombination. | 12095912 |
| Type | IDs |
|---|---|
| Synonymous | AV125803, BB126472 |
| Gene |
UniProtKB-ID:
Q8BZC3_MOUSE,
Q68FG1_MOUSE,
Q3V1X3_MOUSE,
A0A1Y7VMP7_MOUSE
UniprotKB:
Q8BZC3,
Q68FG1,
Q3V1X3,
A0A1Y7VMP7
UniParc:
UPI000042929C,
UPI00005AB83A,
UPI0000419EC8,
UPI00000EA43E
EMBL:
BC079861,
AC159237,
AK132195,
AK035887
Ensembl:
ENSMUSG00000021245
KO:
mmu:217716
|
| Nucleutide sequences |
EMBL-CDS:
BAC29228.1,
AAH79861.1,
BAE21026.1
Ensembl_TRS:
ENSMUST00000166821,
ENSMUST00000019378,
ENSMUST00000220854
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000019378,
ENSMUSP00000129900,
ENSMUSP00000152840
RefSeq:
XP_036013222.1,
XP_006515766.1,
XP_006515769.1,
NP_780546.1,
XP_036013223.1,
XP_006515767.1,
NP_001291404.1
|
| Others |
UniRef100:
UniRef100_Q68FG1,
UniRef100_A0A1Y7VMP7,
UniRef100_Q3V1X3
UniRef90:
UniRef90_Q68FG1
UniRef50:
UniRef50_Q9UHC1
UniGene:
Mm.311981
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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