| Type | Description |
|---|---|
| Definition | L-2-hydroxyglutarate dehydrogenase |
| Date | Results | Publications |
|---|---|---|
| 2017-08-16 17:47:00 | L2hgdh mutation leads to l-2-hydroxyglutarate accumulation, leukoencephalopathy, and neurodegeneration in mice. | 28137912 |
| 2015-12-05 11:10:00 | Data describe a mouse model of L-2-hydroxyglutaric aciduria where mouse with l2hgdh gene deficiency accumulates toxic levels of L-2-hydroxyglutarate mostly in brain and testis and shows significant brain spongiosis and learning deficit. | 25763823 |
| Type | IDs |
|---|---|
| Synonymous | BC016226 |
| Gene |
UniProtKB-ID:
L2HDH_MOUSE
UniprotKB:
Q91YP0
UniParc:
UPI0000021AA2
EMBL:
AK145228,
BC016226,
AK168429,
AK152450
Ensembl:
ENSMUSG00000020988
KO:
mmu:217666
|
| Nucleutide sequences |
EMBL-CDS:
BAE40337.1,
AAH16226.1,
BAE26312.1,
BAE31229.1
Ensembl_TRS:
ENSMUST00000021370
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000021370
RefSeq:
NP_663418.1
|
| Others |
UniRef100:
UniRef100_Q91YP0
UniRef90:
UniRef90_Q91YP0
UniRef50:
UniRef50_Q91YP0
UniGene:
Mm.103362
CCDS:
CCDS25953.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32928875 |
Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney. Dis Model Mech Garrett Brinkley , Hyeyoung Nam , Eunhee Shim , Richard Kirkman , Anirban Kundu , Suman Karki , Yasaman Heidarian , Jason M Tennessen , Juan Liu , Jason W Locasale , Tao Guo , Shi Wei , Jennifer Gordetsky , Teresa L Johnson-Pais , Devin Absher , Dinesh Rakheja , Anil K Challa , Sunil Sudarshan |
2020-11-27 | - |
| 28137912 |
Mol. Cell. Biol. Shenghong Ma , Renqiang Sun , Bowen Jiang , Jun Gao , Wanglong Deng , Peng Liu , Ruoyu He , Jing Cui , Minbiao Ji , Wei Yi , Pengyuan Yang , Xiaohui Wu , Yue Xiong , Zilong Qiu , Dan Ye , Kun-Liang Guan |
2017-04-15 | - |
| 25763823 |
A mouse model of L-2-hydroxyglutaric aciduria, a disorder of metabolite repair. PLoS ONE Rim Rzem , Younes Achouri , Etienne Marbaix , Olivier Schakman , Elsa Wiame , Sandrine Marie , Philippe Gailly , Marie-Françoise Vincent , Maria Veiga-da-Cunha , Emile Van Schaftingen |
2015-01-01 | - |
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 18614015 |
A mitochondrial protein compendium elucidates complex I disease biology. Cell David J Pagliarini , Sarah E Calvo , Betty Chang , Sunil A Sheth , Scott B Vafai , Shao-En Ong , Geoffrey A Walford , Canny Sugiana , Avihu Boneh , William K Chen , David E Hill , Marc Vidal , James G Evans , David R Thorburn , Steven A Carr , Vamsi K Mootha |
2008-07-11 |
Acacb,
Hscb,
Gadd45gip1,
Lars2,
Acad11,
Chchd10,
Nt5dc3,
Slc25a41,
Nt5m,
Cyp27a1,
Acly,
Ndufb11,
Gldc,
Rexo2,
Rars,
Aldh6a1,
Slc25a47,
Rdh14,
Ppif,
Ldhal6b,
Me2,
Glyat,
Slc25a45,
Acaca,
Nt5c3,
Mrpl10,
Mrpl41,
Mrpl30,
Aldh1l1,
Mthfs,
Shmt2,
Atic,
Mthfd1,
Mat2b,
Fam210a,
Gpt2,
Lyrm2,
Rdh13,
Mtrf1l,
Atad3a,
Rars2,
Sccpdh,
Me3,
Maob,
Dut,
Cyp11b1,
Fdps,
Akr7a5,
Msra,
Krt5,
Cox6b1,
Qdpr,
Acat1,
Acat2,
Aldh7a1,
Pcca,
Etfb,
Etfa,
Nudt19,
Acadl,
Acadm,
Acadvl,
Acaa1a,
Acads,
Aco1,
Aco2,
Prosc,
Afg3l1,
Adsl,
Agxt,
Ak2,
Ak4,
Akap1,
Alas1,
Alas2,
Abcd1,
Aldh2,
Aldh3a2,
Gfer,
Acsm1,
Slc25a4,
Slc25a5,
Prdx3,
Prdx6,
Mrps2,
Arg2,
Rhoa,
Atp5a1,
Atp5b,
Atp5c1,
Atp5f1,
Atp5g1,
Atp5j,
Atp5k,
Atpif1,
Auh,
Akr1b7,
Bad,
Bak1
|
| 16141072 |
The transcriptional landscape of the mammalian genome. Science P Carninci , T Kasukawa , S Katayama , J Gough , M C Frith , N Maeda , R Oyama , T Ravasi , B Lenhard , C Wells , R Kodzius , K Shimokawa , V B Bajic , S E Brenner , S Batalov , A R R Forrest , M Zavolan , M J Davis , L G Wilming , V Aidinis , J E Allen , A Ambesi-Impiombato , R Apweiler , R N Aturaliya , T L Bailey , M Bansal , L Baxter , K W Beisel , T Bersano , H Bono , A M Chalk , K P Chiu , V Choudhary , A Christoffels , D R Clutterbuck , M L Crowe , E Dalla , B P Dalrymple , B de Bono , G Della Gatta , D di Bernardo , T Down , P Engstrom , M Fagiolini , G Faulkner , C F Fletcher , T Fukushima , M Furuno , S Futaki , M Gariboldi , P Georgii-Hemming , T R Gingeras , T Gojobori , R E Green , S Gustincich , M Harbers , Y Hayashi , T K Hensch , N Hirokawa , D Hill , L Huminiecki , M Iacono , K Ikeo , A Iwama , T Ishikawa , M Jakt , A Kanapin , M Katoh , Y Kawasawa , J Kelso , H Kitamura , H Kitano , G Kollias , S P T Krishnan , A Kruger , S K Kummerfeld , I V Kurochkin , L F Lareau , D Lazarevic , L Lipovich , J Liu , S Liuni , S McWilliam , M Madan Babu , M Madera , L Marchionni , H Matsuda , S Matsuzawa , H Miki , F Mignone , S Miyake , K Morris , S Mottagui-Tabar , N Mulder , N Nakano , H Nakauchi , P Ng , R Nilsson , S Nishiguchi , S Nishikawa , F Nori , O Ohara , Y Okazaki , V Orlando , K C Pang , W J Pavan , G Pavesi , G Pesole , N Petrovsky , S Piazza , J Reed , J F Reid , B Z Ring , M Ringwald , B Rost , Y Ruan , S L Salzberg , A Sandelin , C Schneider , C Schönbach , K Sekiguchi , C A M Semple , S Seno , L Sessa , Y Sheng , Y Shibata , H Shimada , K Shimada , D Silva , B Sinclair , S Sperling , E Stupka , K Sugiura , R Sultana , Y Takenaka , K Taki , K Tammoja , S L Tan , S Tang , M S Taylor , J Tegner , S A Teichmann , H R Ueda , E van Nimwegen , R Verardo , C L Wei , K Yagi , H Yamanishi , E Zabarovsky , S Zhu , A Zimmer , W Hide , C Bult , S M Grimmond , R D Teasdale , E T Liu , V Brusic , J Quackenbush , C Wahlestedt , J S Mattick , D A Hume , C Kai , D Sasaki , Y Tomaru , S Fukuda , M Kanamori-Katayama , M Suzuki , J Aoki , T Arakawa , J Iida , K Imamura , M Itoh , T Kato , H Kawaji , N Kawagashira , T Kawashima , M Kojima , S Kondo , H Konno , K Nakano , N Ninomiya , T Nishio , M Okada , C Plessy , K Shibata , T Shiraki , S Suzuki , M Tagami , K Waki , A Watahiki , Y Okamura-Oho , H Suzuki , J Kawai , Y Hayashizaki , FANTOM Consortium , RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) |
2005-09-02 | - |
| 16141073 |
Antisense transcription in the mammalian transcriptome. Science S Katayama , Y Tomaru , T Kasukawa , K Waki , M Nakanishi , M Nakamura , H Nishida , C C Yap , M Suzuki , J Kawai , H Suzuki , P Carninci , Y Hayashizaki , C Wells , M Frith , T Ravasi , K C Pang , J Hallinan , J Mattick , D A Hume , L Lipovich , S Batalov , P G Engström , Y Mizuno , M A Faghihi , A Sandelin , A M Chalk , S Mottagui-Tabar , Z Liang , B Lenhard , C Wahlestedt , RIKEN Genome Exploration Research Group , Genome Science Group (Genome Network Project Core Group) , FANTOM Consortium |
2005-09-02 |
Gm14018,
Gm14964,
F630206G17Rik,
Oog3,
Notumos,
Ldlrap1,
Mdn1,
Pydc3,
9330171B17Rik,
Mfap1b,
Tmsb15b2,
Gm12802,
E430020m11rik,
Gm11335,
Gm15772,
Gm17762,
A930017K11Rik,
LOC100036513,
Gata5os,
Umad1,
Gm16982,
Gm9887,
Gm9872,
LOC100036530,
Gm9934,
Gm9913,
Gm11149,
BC028777,
Gm13999,
LOC100036540,
Gm9744,
Gm9983,
D630002J18Rik,
Gm16525,
Gm11696,
Dnajc3,
9430060I03Rik,
Gm12359,
4921516A02Rik,
Fam129c,
Gm10589,
Rsph3b,
Rnaset2a,
5430403G19Rik,
D030047H15Rik,
Gm13274,
B930046K06Rik,
Gm10862,
Gm10792,
Gm10802,
Gm10532,
G730003C15Rik,
Runx2os1,
Gm15612,
Gm10856,
Gm10857,
Gm10685,
Gm10803,
Gm10723,
F630028O10Rik,
Gm10836,
Gm10405,
Gm10513,
Gm10609,
F630201L12Rik,
4932427H20Rik,
Zfp389,
Gm10763,
Gm10062,
Gm10714,
Gm10531,
Gm10876,
Gm10750,
Gm10433,
Gm10837,
Gm10647,
Gm10648,
Gm10650,
Gm10610,
F830115B05Rik,
Gm10473,
Gm10614,
Gm10286,
G730046D07Rik,
Gm10287,
Gm10785,
Gm10183,
Gm10512,
1700061E17Rik,
Gm44113,
Gm10579,
Gm10741,
Gm10827,
Gm10522,
Gm10536,
Gm15998,
Faddos,
D130050E23Rik,
Gm10735
|
| 15840001 |
Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Dev. Growth Differ. Takuya Taniwaki , Kyoko Haruna , Hiroshi Nakamura , Tomohisa Sekimoto , Yuichi Oike , Takashi Imaizumi , Fumiyo Saito , Mayumi Muta , Yumi Soejima , Ayako Utoh , Naomi Nakagata , Masatake Araki , Ken-ichi Yamamura , Kimi Araki |
2005-04-01 |
Lncenc1,
Gm2381,
Gm2679,
Snhg15,
Gm13242,
Rex2,
Ppp4r1l-ps,
Gm17771,
Camta1,
5830417I10Rik,
Ppp1r8,
Gm15545,
Gm12588,
Zfp534,
Trp53cor1,
Gm14401,
Ube3c,
Dhx32,
Mir6236,
Mapkapk3,
Gm32781,
Gm13067,
Gm33628,
Gm34296,
Gm35405,
Gm35911,
Platr3,
Gm38618,
Traf3ip2,
Csnk1g2,
Smg6,
Gm11520,
Cnot6,
4930427A07Rik,
Gm15286,
Gm41259,
Mbnl2,
Slc38a1,
Osbpl11,
Tnfaip8,
Kank1,
Lgr4,
Napa,
Taf9,
Mthfd1,
Foxp1,
Jmjd1c,
Plekha5,
Mbd5,
Kif24,
Tspan9,
Rap1a,
Zfp91,
Rn18s-rs5,
Etfb,
Spred2,
Acvr1,
Mta1,
Pop5,
Anxa11,
Apobec1,
Arf3,
Rab27a,
Zfhx3,
Slc7a1,
Slc7a2,
Bcat1,
Bckdha,
Glb1,
Bmpr1a,
Capzb,
Ctnnb1,
Ctnnd1,
Ccnt1,
Cd81,
Cd9,
Cdyl,
Dnajc5,
Ctbp2,
Celf1,
Cux1,
Dag1,
Dlg1,
Dtnb,
Elf1,
Elk3,
Mark2,
Enah,
Epb41l1,
Epb41l2,
Epn2,
Eps8,
Etv6,
Igf2bp3,
Sfxn1,
Fabp3,
Faf1,
Fgfr1,
Fkbp4
|
| 15489334 |
Genome Res. Daniela S Gerhard , Lukas Wagner , Elise A Feingold , Carolyn M Shenmen , Lynette H Grouse , Greg Schuler , Steven L Klein , Susan Old , Rebekah Rasooly , Peter Good , Mark Guyer , Allison M Peck , Jeffery G Derge , David Lipman , Francis S Collins , Wonhee Jang , Steven Sherry , Mike Feolo , Leonie Misquitta , Eduardo Lee , Kirill Rotmistrovsky , Susan F Greenhut , Carl F Schaefer , Kenneth Buetow , Tom I Bonner , David Haussler , Jim Kent , Mark Kiekhaus , Terry Furey , Michael Brent , Christa Prange , Kirsten Schreiber , Nicole Shapiro , Narayan K Bhat , Ralph F Hopkins , Florence Hsie , Tom Driscoll , M Bento Soares , Tom L Casavant , Todd E Scheetz , Michael J Brown-stein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Yulan Piao , Dawood B Dudekula , Minoru S H Ko , Koichi Kawakami , Yutaka Suzuki , Sumio Sugano , C E Gruber , M R Smith , Blake Simmons , Troy Moore , Richard Waterman , Stephen L Johnson , Yijun Ruan , Chia Lin Wei , S Mathavan , Preethi H Gunaratne , Jiaqian Wu , Angela M Garcia , Stephen W Hulyk , Edwin Fuh , Ye Yuan , Anna Sneed , Carla Kowis , Anne Hodgson , Donna M Muzny , John McPherson , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madari , Alice C Young , Keith D Wetherby , Steven J Granite , Peggy N Kwong , Charles P Brinkley , Russell L Pearson , Gerard G Bouffard , Robert W Blakesly , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Malachi Griffith , Obi L Griffith , Martin I Krzywinski , Nancy Liao , Ryan Morin , Ryan Morrin , Diana Palmquist , Anca S Petrescu , Ursula Skalska , Duane E Smailus , Jeff M Stott , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Robert A Holt , Agnes Baross , Marco A Marra , Sandra Clifton , Kathryn A Makowski , Stephanie Bosak , Joel Malek , MGC Project Team |
2004-10-01 |
Ldlrap1,
Dnajc3,
Rnaset2a,
Btnl1,
Isg15,
Cyp3a41b,
Ly6c2,
Ccl21b,
Eif3j2,
Mup18,
Lrrc19,
Rcc1,
1700047I17Rik2,
Pcsk9,
Adat3,
Tdrd7,
Sco2,
Gpr153,
Pafah2,
Gm44504,
H6pd,
Adprhl2,
Gpn2,
Rusc2,
Stx12,
Ppp1r8,
Smpdl3b,
Fam46b,
Bsdc1,
Slc44a1,
Zfand2a,
Rubcn,
Kifc1,
Pifo,
C030017K20Rik,
Cbarp,
Rpl5,
Micalcl,
Atg14,
Lrrc8c,
Noc4l,
Nsun5,
Psph,
Trrap,
Mapre3,
Ube3c,
Tbc1d14,
Hscb,
Tyw1,
Emilin1,
Rab28,
Pot1a,
Parp11,
Tada3,
Tra2a,
Brk1,
Fbxl14,
Phrf1,
Plekha1,
Gm21975,
Ric8a,
Mob2,
Prkd2,
Ccp110,
Vrk3,
Grwd1,
Nlrp6,
Trim68,
Psip1,
Spred3,
Faap24,
Ints4,
Rrp8,
Unc45a,
Igflr1,
Sf3b3,
D8Ertd738e,
Usb1,
Champ1,
Smim19,
Exoc8,
Gadd45gip1,
Phkb,
Dohh,
Fam192a,
Enkd1,
Taf5l,
Zdhhc7,
Snapc2,
Ak6,
Gpat4,
Dcun1d2,
Ankrd10,
Cog4,
Hinfp,
Lars2,
Xylb,
Imp3,
Cmtm7
|
| 14681479 |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. Axel Visel , Christina Thaller , Gregor Eichele |
2004-01-01 |
Rnaset2a,
Mthfsl,
Tgtp2,
Gm11273,
Gm3063,
Gm9833,
Zkscan16,
Amd2,
Gm3776,
Gm3934,
Gm10681,
Gm4450,
Cyp2j11,
Camta1,
Zbtb48,
Sco2,
Pafah2,
Akna,
H6pd,
Smpdl3b,
Lao1,
Kifc1,
Gm20186,
Ugt2b38,
Slc15a4,
Psph,
Acacb,
Pds5b,
Ugt2b34,
Ube3c,
Hsd3b7,
Ano1,
Gpat4,
Lars2,
Xylb,
Slc22a13,
Rpp25,
Acad11,
Slc6a8,
Slc6a15,
Upb1,
Mgat4b,
Xpo1,
Slc35e4,
Pnpo,
Slc25a41,
Nt5m,
Rpn1,
Gck,
Synj1,
Cyp27a1,
Adcy4,
Adcy3,
Acly,
Ces1d,
Gldc,
Sbk1,
Barhl2,
E2f4,
Dgkz,
Rars,
Cnot6,
Slc16a6,
Aldh6a1,
Adi1,
Rdh14,
Iars,
Akr1c18,
Dusp22,
Gmpr2,
Thtpa,
Espl1,
Slc45a4,
Stk38,
Tecr,
Ldhal6b,
Ppcs,
Cyp4f15,
Slc39a3,
Slc39a6,
Me2,
Lars,
Cyp2c50,
Carns1,
Yars,
Psat1,
Slc25a45,
Acaca,
Atf5,
Eprs,
Nt5c3,
Dio3,
Ovol2,
Pi4kb,
Uap1,
Slc12a6,
Aldh1l1,
Haao,
Scml2
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员