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21748 Terc

21748

Terc

telomerase RNA component

ncRNA

Mus musculus

基因描述

Type Description
Definition telomerase RNA component

研究结论

Date Results Publications
2020-05-23 13:05:00 TERC association with mTor pathway and its role in aging. 32127537
2020-05-16 10:47:00 The authors show that cytosolic TERC-53 is involved in cognition decline in 10 months old mouse hippocampus without affecting telomerase activity or mitochondrial functions, possibly through regulating nuclear gene expression. 30788732
2019-06-29 10:40:00 The telomere lengths are longest in wild-type but shortest in Terc(-/-) ntESCs. 30870992
2019-06-08 10:36:00 Mechanistically, Gadd45a facilitates the generation of a permissive chromatin state for DNA damage response (DDR) signaling by inducing base excision repair-dependent demethylation of CpG islands specifically at sub-telomeric regions of short telomeres. Deletion of Gadd45a promotes chromatin compaction in sub-telomeric regions and attenuates DDR initiation at short telomeres of G3Terc (-/-) ISCs 30126922
2018-02-24 10:14:00 Expression of functional alternative telomerase RNA component gene in the mouse brain provides an additional way for regulating telomerase activity under normal and stress conditions and confers protection to neuronal cells from oxidative stress. 27823970

名称对应

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Type IDs
Synonymous mTER, mTR