| Type | Description |
|---|---|
| Definition | ubiquitin-conjugating enzyme E2O |
| Date | Results | Publications |
|---|---|---|
| 2020-07-25 12:03:00 | Through phenotype analysis of high-fat diet-induced obesity and metabolic syndrome mice with muscle-, fat-, or liver-specific knockout of Ube2o, study identified Ube2o as an essential regulator of glucose and lipid metabolism programs in skeletal muscle, but not in adipose or liver tissue. Mechanistically, Ube2o acted as a ubiquitin ligase and targeted AMPKalpha2 for ubiquitin-dependent degradation in skeletal muscles. | 31292296 |
| 2019-02-09 12:05:00 | This work identifies UBE2O as a critical regulator in the ubiquitin-proteasome system, which modulates BMAL1 transcriptional activity and circadian function by promoting BMAL1 ubiquitination and degradation under normal physiological conditions. | 29871923 |
| 2018-01-13 12:39:00 | UBE2O recognized ribosomal proteins and other substrates directly, targeting them to proteasomes for degradation. | 28774900 |
| 2013-05-25 10:34:00 | monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O and SMAD6 cooperated in the regulation of BMP7-induced adipogenesis | 23455153 |
| Type | IDs |
|---|---|
| Synonymous | 9630022H21, B230113M03Rik, E2-230K, mKIAA1734 |
| Gene |
UniProtKB-ID:
UBE2O_MOUSE
UniprotKB:
Q6ZPJ3
UniParc:
UPI00001E6AA7
EMBL:
AK129431,
U20780,
BC059193,
AL645851,
AL607039,
AK045398
Ensembl:
ENSMUSG00000020802
KO:
mmu:217342
|
| Nucleutide sequences |
EMBL-CDS:
AAH59193.1,
AAA69916.1,
BAC98241.1,
BAC32345.1
Ensembl_TRS:
ENSMUST00000082152
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000080791
RefSeq:
XP_011247262.1,
NP_776116.2,
XP_006533169.1
|
| Others |
UniRef100:
UniRef100_Q6ZPJ3
UniRef90:
UniRef90_Q9C0C9
UniRef50:
UniRef50_Q9C0C9
UniGene:
Mm.243950
CCDS:
CCDS25670.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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