Fnip1 - folliculin interacting protein 1-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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216742 Fnip1

基因描述

Type	Description
Definition	folliculin interacting protein 1

研究结论

Date	Results	Publications
2020-05-30 11:55:00	The results indicate that Fnip1 modulates autophagy and energy response pathways in part through the regulation of AMPK, mTORC1, and TFE3 in B cell progenitors.	31676673
2018-12-22 11:21:00	Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation	29897930
2018-12-01 12:26:00	These findings suggest that Dihydromyricetin treatment prevents palmitate-induced slow-twitch fibers decrease partially via FLCN-FNIP1-AMPK pathway thereby improving insulin resistance in obesity.	28363698
2017-12-16 12:25:00	FNIP1-deficient mice developed cardiomyopathy characterized by left ventricular hypertrophy and glycogen accumulation.	27303042
2017-09-16 13:01:00	Mechanistically, miR-499 directly targets Fnip1, an AMP-activated protein kinase (AMPK)-interacting protein that negatively regulates AMPK, a known activator of PGC-1alpha. This miR-499/Fnip1/AMPK circuit can serve as a mechanism to couple muscle fiber type and mitochondrial function.	27506764

名称对应

Type	IDs
Synonymous	A730024A03Rik, AI838773, AW557298
Gene	UniProtKB-ID: FNIP1_MOUSE UniprotKB: Q68FD7 UniParc: UPI00001E5A84 EMBL: AL596127, BC079892, AK122574, AK047814 Ensembl: ENSMUSG00000035992 KO: mmu:216742
Nucleutide sequences	EMBL-CDS: AAH79892.1, BAC33163.1, BAC65856.1 Ensembl_TRS: ENSMUST00000046835
Protein sequencees	Ensembl_PRO: ENSMUSP00000049026 RefSeq: XP_006532911.1, XP_006532910.1, XP_006532912.1, NP_776114.2
Others	UniRef100: UniRef100_Q68FD7 UniRef90: UniRef90_Q68FD7 UniRef50: UniRef50_Q8TF40 UniGene: Mm.34087 CCDS: CCDS24698.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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Pubmed编号	文献信息	发表日期	相关基因
32325033	BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Cell Syst Reza Pourhaghighi , Peter E A Ash , Sadhna Phanse , Florian Goebels , Lucas Z M Hu , Siwei Chen , Yingying Zhang , Shayne D Wierbowski , Samantha Boudeau , Mohamed T Moutaoufik , Ramy H Malty , Edyta Malolepsza , Kalliopi Tsafou , Aparna Nathan , Graham Cromar , Hongbo Guo , Ali Al Abdullatif , Daniel J Apicco , Lindsay A Becker , Aaron D Gitler , Stefan M Pulst , Ahmed Youssef , Ryan Hekman , Pierre C Havugimana , Carl A White , Benjamin C Blum , Antonia Ratti , Camron D Bryant , John Parkinson , Kasper Lage , Mohan Babu , Haiyuan Yu , Gary D Bader , Benjamin Wolozin , Andrew Emili	2020-04-22	-
31676673	Folliculin Interacting Protein 1 Maintains Metabolic Homeostasis during B Cell Development by Modulating AMPK, mTORC1, and TFE3. J Immunol Julita A RamÃrez , Terri Iwata , Heon Park , Mark Tsang , Janella Kang , Katy Cui , Winnie Kwong , Richard G James , Masaya Baba , Laura S Schmidt , Brian M Iritani	2019-12-01	-
29897930	Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation. PLoS ONE Ryan Centini , Mark Tsang , Terri Iwata , Heon Park , Jeffrey Delrow , Daciana Margineantu , Brandon M Iritani , Haiwei Gu , H Denny Liggitt , Janella Kang , Lim Kang , David M Hockenbery , Daniel Raftery , Brian M Iritani	2018-01-01	-
29097735	Mammalian Î³2 AMPK regulates intrinsic heart rate. Nat Commun Arash Yavari , Mohamed Bellahcene , Annalisa Bucchi , Syevda Sirenko , Katalin Pinter , Neil Herring , Julia J Jung , Kirill V Tarasov , Emily J Sharpe , Markus Wolfien , Gabor Czibik , Violetta Steeples , Sahar Ghaffari , Chinh Nguyen , Alexander Stockenhuber , Joshua R St Clair , Christian Rimmbach , Yosuke Okamoto , Dongmei Yang , Mingyi Wang , Bruce D Ziman , Jack M Moen , Daniel R Riordon , Christopher Ramirez , Manuel Paina , Joonho Lee , Jing Zhang , Ismayil Ahmet , Michael G Matt , Yelena S Tarasova , Dilair Baban , Natasha Sahgal , Helen Lockstone , Rathi Puliyadi , Joseph de Bono , Owen M Siggs , John Gomes , Hannah Muskett , Mahon L Maguire , Youlia Beglov , Matthew Kelly , Pedro P N Dos Santos , Nicola J Bright , Angela Woods , Katja Gehmlich , Henrik Isackson , Gillian Douglas , David J P Ferguson , JÃ¼rgen E Schneider , Andrew Tinker , Olaf Wolkenhauer , Keith M Channon , Richard J Cornall , Eduardo B Sternick , David J Paterson , Charles S Redwood , David Carling , Catherine Proenza , Robert David , Mirko Baruscotti , Dario DiFrancesco , Edward G Lakatta , Hugh Watkins , Houman Ashrafian	2017-11-02	-
28363698	Dihydromyricetin prevents obesity-induced slow-twitch-fiber reduction partially via FLCN/FNIP1/AMPK pathway. Biochim Biophys Acta Mol Basis Dis Qicheng Zhou , Yeyun Gu , Hedong Lang , Xiaolan Wang , Ka Chen , Xinhua Gong , Min Zhou , Li Ran , Jundong Zhu , Mantian Mi	2017-06-01	-
27506764	Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit. EMBO Mol Med Jing Liu , Xijun Liang , Danxia Zhou , Ling Lai , Liwei Xiao , Lin Liu , Tingting Fu , Yan Kong , Qian Zhou , Rick B Vega , Min-Sheng Zhu , Daniel P Kelly , Xiang Gao , Zhenji Gan	2016-10-01	-
27303042	Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity. Proc Natl Acad Sci U S A Owen M Siggs , Alexander Stockenhuber , Mukta Deobagkar-Lele , Katherine R Bull , Tanya L Crockford , Bethany L Kingston , Greg Crawford , Consuelo Anzilotti , Violetta Steeples , Sahar Ghaffari , Gabor Czibik , Mohamed Bellahcene , Hugh Watkins , Houman Ashrafian , Benjamin Davies , Angela Woods , David Carling , Arash Yavari , Bruce Beutler , Richard J Cornall	2016-06-28	-
25775561	Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn. Proc. Natl. Acad. Sci. U.S.A. Hisashi Hasumi , Masaya Baba , Yukiko Hasumi , Martin Lang , Ying Huang , HyoungBin F Oh , Masayuki Matsuo , Maria J Merino , Masahiro Yao , Yusuke Ito , Mitsuko Furuya , Yasuhiro Iribe , Tatsuhiko Kodama , Eileen Southon , Lino Tessarollo , Kunio Nagashima , Diana C Haines , W Marston Linehan , Laura S Schmidt	2015-03-31	Fnip1, Flcn, Fnip2
25548157	Fnip1 regulates skeletal muscle fiber type specification, fatigue resistance, and susceptibility to muscular dystrophy. Proc. Natl. Acad. Sci. U.S.A. Nicholas L Reyes , Glen B Banks , Mark Tsang , Daciana Margineantu , Haiwei Gu , Danijel Djukovic , Jacky Chan , Michelle Torres , H Denny Liggitt , Dinesh K Hirenallur-S , David M Hockenbery , Daniel Raftery , Brian M Iritani	2015-01-13	Dmd, Ppargc1a, Fnip1
24785297	Metabolic regulator Fnip1 is crucial for iNKT lymphocyte development. Proc. Natl. Acad. Sci. U.S.A. Heon Park , Mark Tsang , Brian M Iritani , Michael J Bevan	2014-05-13	Bcl2l11, Ighm, Il2rg, Rag2, Fnip1

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