| Type | Description |
|---|---|
| Definition | thymine DNA glycosylase |
| Date | Results | Publications |
|---|---|---|
| 2018-03-03 10:14:00 | These findings suggest that the catalytic and scaffolding activities of TDG are essential for retinoic acid-dependent gene expression and provide important insights into the mechanisms underlying targeting of TET-TDG complexes. | 28538185 |
| 2016-06-11 12:19:00 | The DNA demethylation marks are dynamically regulated in both in vivo and in vitro aging conditions, which are associated with Tet3 over-expression and Tdg repression. | 25982203 |
| 2015-04-11 12:26:00 | TDG, as a new coactivator, promotes beta-catenin/TCFs transactivation and functionally cooperates with CBP in canonical Wnt signaling. | 24748645 |
| 2012-04-28 11:06:00 | Embryonic lethality in Tdg (-/-) embryos is due, in part, to the reduction of noradrenaline levels. | 22200605 |
| 2011-09-17 11:04:00 | data suggest that oxidation of 5-methylcytosine by Tet proteins followed by TDG-mediated base excision of 5-carboxylcytosine constitutes a pathway for active DNA demethylation | 21817016 |
| Type | IDs |
|---|---|
| Synonymous | E130317C12Rik, JZA-3, Jza1 |
| Gene |
UniProtKB-ID:
TDG_MOUSE
UniprotKB:
P56581
UniParc:
UPI0000455FE1,
UPI00005652BD
EMBL:
AF069519,
BC010315,
AK053870,
CH466540,
AK169768,
BC085470,
BC085471,
AC152980,
AK164643,
AK164090,
AK089915
Ensembl:
ENSMUSG00000034674
KO:
mmu:21665
|
| Nucleutide sequences |
EMBL-CDS:
AAH85471.1,
BAE37857.1,
EDL04997.1,
AAC31900.1,
BAE37621.1,
BAE41355.1,
BAC40994.1,
AAH10315.2,
BAC35566.1,
AAH85470.1
Ensembl_TRS:
ENSMUST00000092266,
ENSMUST00000151390
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000089917,
ENSMUSP00000121000
RefSeq:
XP_030100908.1,
NP_766140.2,
NP_035691.2,
NP_001345446.1
|
| Others |
UniRef100:
UniRef100_P56581
UniRef90:
UniRef90_P56581
UniRef50:
UniRef50_P56581
UniGene:
Mm.347607
CCDS:
CCDS36013.1,
CCDS24070.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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