| Type | Description |
|---|---|
| Definition | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 |
| Date | Results | Publications |
|---|---|---|
| 2018-04-28 12:02:00 | Dopamine and DOPAC were not changed in 3-mo-old mice but were decreased at 8 mo in the striatum of PIKE-KO mice compared with wild-type mice. DA and DOPAC in hippocampus and substantia nigra were significantly decreased in 3-mo-old and 8-mo-old PIKE-KO mice as compared with wild-type mice. More severe motor defects in PIKE-KO and Fyn-KO mice than in wild-type mice exposed to alpha synuclein and MPTP. | 28096359 |
| 2017-09-02 11:00:00 | Depletion of PIKE-A in C2C12 myotubes diminished the inhibitory activities of TNF-alpha on mitochondrial respiration and lipid oxidation, whereas PIKE-A overexpression exacerbated these cellular responses. | 28404596 |
| 2014-04-05 10:57:00 | PIKE plays pivotal roles to advance oligodendroglia development and myelinogenesis through Akt/mTOR activation. | 24449917 |
| 2013-06-29 12:41:00 | Results demonstrate that the integrity of PIKE signaling is essential for protecting the neurons from excitotoxicity-stimulated damage both in vitro and in vivo. | 21925531 |
| 2013-06-01 12:35:00 | Fyn regulates the activity of the adipogenic transcription factor signal transducer and activator of transcription 5a through enhancing its interaction with the GTPase phosphoinositide 3-kinase enhancer A (PIKE-A). | 23438599 |
| Type | IDs |
|---|---|
| Synonymous | AGAP-2, Centg1, PIKE, cnt-g1, mKIAA0167 |
| Gene |
UniProtKB-ID:
AGAP2_MOUSE
UniprotKB:
Q3UHD9
UniParc:
UPI0000D6340D,
UPI000024E230
EMBL:
AK147446,
AK220325
Ensembl:
ENSMUSG00000025422
KO:
mmu:216439
|
| Nucleutide sequences |
EMBL-CDS:
BAE27918.1,
BAD90236.1
Ensembl_TRS:
ENSMUST00000039259,
ENSMUST00000217941
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000151946,
ENSMUSP00000043466
RefSeq:
XP_006513626.1,
NP_001287943.1,
XP_006513622.1,
XP_006513621.1,
XP_006513625.1,
NP_001028435.1,
XP_006513624.1
|
| Others |
UniRef100:
UniRef100_Q3UHD9
UniRef90:
UniRef90_Q8CGU4
UniRef50:
UniRef50_Q8CGU4
UniGene:
Mm.336761
CCDS:
CCDS88097.1,
CCDS24228.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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