| Type | Description |
|---|---|
| Definition | tryptophan hydroxylase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:33:00 | Stress-induced aggression in heterozygous TPH2 mutant mice is associated with alterations in serotonin turnover and expression of 5-HT6 and AMPA subunit 2A receptors. | 32553388 |
| 2020-09-19 16:23:00 | Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice. | 31319134 |
| 2020-08-22 15:24:00 | Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2. | 30472790 |
| 2020-06-20 10:31:00 | Study used Tph2 +/+APP/PS1 mice and Tph2 -/-APP/PS1 mice at 6 months (6m), 8 months (8m), and 10 months (10m) to assess the roles of Tph2 in the formation of senile plaques. Reported density changes of GFAP+ astrocytes, colocalization between Abeta plaques or neurons and autophagy markers LC3, P62. Results indicate that Tph2 CKO can exacerbate neuropathological characteristics of Abeta in Alzheimer's disease mice. | 30827242 |
| 2020-04-11 12:54:00 | Effect of the C1473G Polymorphic Variant of the Tryptophan Hydroxylase 2 Gene and Photoperiod Length on the Dopamine System of the Mouse Brain | 32163389 |
| Type | IDs |
|---|---|
| Synonymous | AU043594, Ntph |
| Gene |
UniProtKB-ID:
TPH2_MOUSE
UniprotKB:
Q8CGV2
UniParc:
UPI0000DBDD4F
EMBL:
AY090565,
BC125430,
BC120514
Ensembl:
ENSMUSG00000006764
KO:
mmu:216343
|
| Nucleutide sequences |
EMBL-CDS:
AAI20515.1,
AAM08923.1,
AAI25431.1
Ensembl_TRS:
ENSMUST00000006949
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000006949
RefSeq:
NP_775567.2
|
| Others |
UniRef100:
UniRef100_Q8CGV2
UniRef90:
UniRef90_Q8IWU9
UniRef50:
UniRef50_Q8IWU9
UniGene:
Mm.31597
CCDS:
CCDS36061.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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