| Type | Description |
|---|---|
| Definition | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:33:00 | The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic beta-cells. | 33122440 |
| 2019-03-02 12:42:00 | APPL2 overexpression could blunt the activation of glucocorticoid receptor when undergoing environmental stress. | 28965332 |
| 2017-10-28 12:30:00 | Here we establish potential roles for APPL1 and 2 signaling adaptors as regulators of LPS/TLR4-induced signaling, transcription, and cytokine secretion. | 27219021 |
| 2016-06-11 11:26:00 | Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF-induced Akt activation, migration, and invasion. | 26445298 |
| 2015-10-31 10:53:00 | Rab31, with APPL2 as its effector, play a role in FcgammaR-mediated phagocytosis through PI3K/Akt signaling in macrophages. | 25568335 |
| Type | IDs |
|---|---|
| Synonymous | DIP13 beta, Dip3 beta, Dip3b |
| Gene |
UniProtKB-ID:
DP13B_MOUSE,
Q3TVI6_MOUSE
UniprotKB:
Q8K3G9,
Q3TVI6
UniParc:
UPI00000289C3
EMBL:
AK160105,
BC048906,
AY113706,
AK160075,
BC002232
Ensembl:
ENSMUSG00000020263
KO:
mmu:216190
|
| Nucleutide sequences |
EMBL-CDS:
AAM55532.1,
AAH48906.1,
AAH02232.1,
BAE35609.1,
BAE35632.1
Ensembl_TRS:
ENSMUST00000020500
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000020500
RefSeq:
XP_017169384.1,
XP_006513571.1,
NP_660255.1,
XP_036011638.1,
XP_030100886.1,
XP_036011641.1,
XP_036011640.1,
XP_036011642.1,
XP_036011639.1,
XP_006513573.1,
XP_006513574.1,
XP_036011637.1,
XP_030100887.1,
XP_006513572.1
|
| Others |
UniRef100:
UniRef100_Q8K3G9
UniRef90:
UniRef90_Q8K3G9
UniRef50:
UniRef50_Q8NEU8
UniGene:
Mm.282985
CCDS:
CCDS24078.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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