| Type | Description |
|---|---|
| Definition | transmembrane protein 259 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 10:55:00 | reduced membralin and EAAT2 levels correlated with disease progression in spinal cord from SOD1-mutant mouse models, and reductions in membralin/EAAT2 were observed in human ALS spinal cord. Importantly, overexpression of membralin in SOD1G93A astrocytes decreased TNFR1 levels and increased EAAT2 expression, and improved motor neuron survival. | 31112137 |
| 2018-09-15 10:25:00 | The results identify membralin as an Endoplasmic-reticulum-associated degradation component and demonstrate a critical role for Endoplasmic-reticulum-associated degradation in Alzheimer's disease pathogenesis. | 29133892 |
| 2016-03-12 11:02:00 | Membralin plays a critical role in motor neuron survival, suggesting a novel mechanism for early-onset motor neuron disease. | 25977983 |
| 2010-01-21 00:00:00 | genomic organization and expression (membralin) | 12638133 |
| Type | IDs |
|---|---|
| Synonymous | AC087114.7gm2, ORF61, R32184_3, mFLJ00277 |
| Gene |
UniProtKB-ID:
MBRL_MOUSE
UniprotKB:
Q8CIV2
UniParc:
UPI00001E50BD,
UPI00001E50C1
EMBL:
AY096036,
AK131170,
AY096037,
BC052787,
BC005494
Ensembl:
ENSMUSG00000013858
KO:
mmu:216157
|
| Nucleutide sequences |
EMBL-CDS:
AAM34492.1,
AAH05494.1,
AAH52787.1,
BAD21420.1,
AAM34493.1
Ensembl_TRS:
ENSMUST00000052885
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000056792
RefSeq:
XP_006513554.1,
NP_001003949.2,
NP_001346561.1
|
| Others |
UniRef100:
UniRef100_Q8CIV2
UniRef90:
UniRef90_Q8CIV2
UniRef50:
UniRef50_Q8CIV2
UniGene:
Mm.29442
CCDS:
CCDS24002.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 31112137 |
Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment. J Clin Invest Lu-Lin Jiang , Bing Zhu , Yingjun Zhao , Xiaoguang Li , Tongfei Liu , Juan Pina-Crespo , Lisa Zhou , Wenxi Xu , Maria J Rodriguez , Haiyang Yu , Don W Cleveland , John Ravits , Sandrine Da Cruz , Tao Long , Dongxian Zhang , Timothy Y Huang , Huaxi Xu |
2019-05-21 | - |
| 30704515 |
Acta Neuropathol Commun Hermeto Gerber , Sebastien Mosser , Benjamin Boury-Jamot , Michael Stumpe , Alessandra Piersigilli , Christine Goepfert , Joern Dengjel , Urs Albrecht , Fulvio Magara , Patrick C Fraering |
2019-01-31 | - |
| 29133892 |
Nat Commun Bing Zhu , LuLin Jiang , Timothy Huang , Yingjun Zhao , Tongfei Liu , Yongwang Zhong , Xiaoguang Li , Alexandre Campos , Kenneth Pomeroy , Eliezer Masliah , Dongxian Zhang , Huaxi Xu |
2017-11-13 | - |
| 28671696 |
Nat. Neurosci. Jing Li , Wangshu Zhang , Hui Yang , Daniel P Howrigan , Brent Wilkinson , Tade Souaiaia , Oleg V Evgrafov , Giulio Genovese , Veronica A Clementel , Jennifer C Tudor , Ted Abel , James A Knowles , Benjamin M Neale , Kai Wang , Fengzhu Sun , Marcelo P Coba |
2017-08-01 | - |
| 25977983 |
The critical role of membralin in postnatal motor neuron survival and disease. Elife Bo Yang , Mingliang Qu , Rengang Wang , Jon E Chatterton , Xiao-Bo Liu , Bing Zhu , Sonoko Narisawa , Jose Luis Millan , Nobuki Nakanishi , Kathryn Swoboda , Stuart A Lipton , Dongxian Zhang |
2015-01-01 |
Grin3b,
Tmem259,
Erlin2
|
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 21677750 |
A conditional knockout resource for the genome-wide study of mouse gene function. Nature William C Skarnes , Barry Rosen , Anthony P West , Manousos Koutsourakis , Wendy Bushell , Vivek Iyer , Alejandro O Mujica , Mark Thomas , Jennifer Harrow , Tony Cox , David Jackson , Jessica Severin , Patrick Biggs , Jun Fu , Michael Nefedov , Pieter J de Jong , A Francis Stewart , Allan Bradley |
2011-06-15 | - |
| 21267068 |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. Graciana Diez-Roux , Sandro Banfi , Marc Sultan , Lars Geffers , Santosh Anand , David Rozado , Alon Magen , Elena Canidio , Massimiliano Pagani , Ivana Peluso , Nathalie Lin-Marq , Muriel Koch , Marchesa Bilio , Immacolata Cantiello , Roberta Verde , Cristian De Masi , Salvatore A Bianchi , Juliette Cicchini , Elodie Perroud , Shprese Mehmeti , Emilie Dagand , Sabine Schrinner , Asja Nürnberger , Katja Schmidt , Katja Metz , Christina Zwingmann , Norbert Brieske , Cindy Springer , Ana Martinez Hernandez , Sarah Herzog , Frauke Grabbe , Cornelia Sieverding , Barbara Fischer , Kathrin Schrader , Maren Brockmeyer , Sarah Dettmer , Christin Helbig , Violaine Alunni , Marie-Annick Battaini , Carole Mura , Charlotte N Henrichsen , Raquel Garcia-Lopez , Diego Echevarria , Eduardo Puelles , Elena Garcia-Calero , Stefan Kruse , Markus Uhr , Christine Kauck , Guangjie Feng , Nestor Milyaev , Chuang Kee Ong , Lalit Kumar , MeiSze Lam , Colin A Semple , Attila Gyenesei , Stefan Mundlos , Uwe Radelof , Hans Lehrach , Paolo Sarmientos , Alexandre Reymond , Duncan R Davidson , Pascal Dollé , Stylianos E Antonarakis , Marie-Laure Yaspo , Salvador Martinez , Richard A Baldock , Gregor Eichele , Andrea Ballabio |
2011-01-18 | - |
| 15489334 |
Genome Res. Daniela S Gerhard , Lukas Wagner , Elise A Feingold , Carolyn M Shenmen , Lynette H Grouse , Greg Schuler , Steven L Klein , Susan Old , Rebekah Rasooly , Peter Good , Mark Guyer , Allison M Peck , Jeffery G Derge , David Lipman , Francis S Collins , Wonhee Jang , Steven Sherry , Mike Feolo , Leonie Misquitta , Eduardo Lee , Kirill Rotmistrovsky , Susan F Greenhut , Carl F Schaefer , Kenneth Buetow , Tom I Bonner , David Haussler , Jim Kent , Mark Kiekhaus , Terry Furey , Michael Brent , Christa Prange , Kirsten Schreiber , Nicole Shapiro , Narayan K Bhat , Ralph F Hopkins , Florence Hsie , Tom Driscoll , M Bento Soares , Tom L Casavant , Todd E Scheetz , Michael J Brown-stein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Yulan Piao , Dawood B Dudekula , Minoru S H Ko , Koichi Kawakami , Yutaka Suzuki , Sumio Sugano , C E Gruber , M R Smith , Blake Simmons , Troy Moore , Richard Waterman , Stephen L Johnson , Yijun Ruan , Chia Lin Wei , S Mathavan , Preethi H Gunaratne , Jiaqian Wu , Angela M Garcia , Stephen W Hulyk , Edwin Fuh , Ye Yuan , Anna Sneed , Carla Kowis , Anne Hodgson , Donna M Muzny , John McPherson , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madari , Alice C Young , Keith D Wetherby , Steven J Granite , Peggy N Kwong , Charles P Brinkley , Russell L Pearson , Gerard G Bouffard , Robert W Blakesly , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Malachi Griffith , Obi L Griffith , Martin I Krzywinski , Nancy Liao , Ryan Morin , Ryan Morrin , Diana Palmquist , Anca S Petrescu , Ursula Skalska , Duane E Smailus , Jeff M Stott , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Robert A Holt , Agnes Baross , Marco A Marra , Sandra Clifton , Kathryn A Makowski , Stephanie Bosak , Joel Malek , MGC Project Team |
2004-10-01 |
Ldlrap1,
Dnajc3,
Rnaset2a,
Btnl1,
Isg15,
Cyp3a41b,
Ly6c2,
Ccl21b,
Eif3j2,
Mup18,
Lrrc19,
Rcc1,
1700047I17Rik2,
Pcsk9,
Adat3,
Tdrd7,
Sco2,
Gpr153,
Pafah2,
Gm44504,
H6pd,
Adprhl2,
Gpn2,
Rusc2,
Stx12,
Ppp1r8,
Smpdl3b,
Fam46b,
Bsdc1,
Slc44a1,
Zfand2a,
Rubcn,
Kifc1,
Pifo,
C030017K20Rik,
Cbarp,
Rpl5,
Micalcl,
Atg14,
Lrrc8c,
Noc4l,
Nsun5,
Psph,
Trrap,
Mapre3,
Ube3c,
Tbc1d14,
Hscb,
Tyw1,
Emilin1,
Rab28,
Pot1a,
Parp11,
Tada3,
Tra2a,
Brk1,
Fbxl14,
Phrf1,
Plekha1,
Gm21975,
Ric8a,
Mob2,
Prkd2,
Ccp110,
Vrk3,
Grwd1,
Nlrp6,
Trim68,
Psip1,
Spred3,
Faap24,
Ints4,
Rrp8,
Unc45a,
Igflr1,
Sf3b3,
D8Ertd738e,
Usb1,
Champ1,
Smim19,
Exoc8,
Gadd45gip1,
Phkb,
Dohh,
Fam192a,
Enkd1,
Taf5l,
Zdhhc7,
Snapc2,
Ak6,
Gpat4,
Dcun1d2,
Ankrd10,
Cog4,
Hinfp,
Lars2,
Xylb,
Imp3,
Cmtm7
|
| 15449545 |
DNA Res. Noriko Okazaki , Reiko Kikuno , Reiko Ohara , Susumu Inamoto , Haruhiko Koseki , Shuichi Hiraoka , Yumiko Saga , Hiroshi Kitamura , Tomoko Nakagawa , Takahiro Nagase , Osamu Ohara , Hisashi Koga |
2004-04-30 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员