| Type | Description |
|---|---|
| Definition | ras homolog family member T2 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-04 10:17:00 | Mitochondrial Miro2 expression levels regulate inter-mitochondrial communication along microtubules in adult cardiomyocytes. Degradation of Miro2 through Parkin-mediated ubiquitination contributes to impaired inter-mitochondrial communication and cardiac dysfunction during hypertrophic heart diseases. | 31455181 |
| 2020-01-18 12:48:00 | Using knockout mouse embryonic fibroblasts, data show that mitochondrial Rho (Miro) GTPases Miro1 and Miro2 are required for normal mitochondrial cristae architecture and endoplasmic reticulum-mitochondria contacts Sites (ERMCS). | 31562315 |
| 2019-10-26 12:39:00 | we show for the first time that inhibition of NOS3 generation in glial cells prevents axonal mitochondrial fission and restores mitochondrial motility to confer protection to axons by preserving Miro-2 levels | 29891729 |
| 2019-09-21 10:23:00 | Due to the multifunctionality of CENP-F, the cellular phenotypes observed upon its depletion are difficult to interpret and there is a need to genetically separate its different functions by preventing binding to selected partners. Here we engineer a CENP-F point-mutant that is deficient in Miro1/2 binding and thus is unable to localize to mitochondria, but retains other localizations. | 30856164 |
| 2018-10-13 10:29:00 | both Miro proteins can act to coordinate microtubule-dependent and actin-dependent mitochondrial trafficking, Miro1 preferentially acts to control microtubule-dependent trafficking through kinesin and dynein, while Miro2 plays a more prominent role in coordinating mitochondrial interactions with the actin cytoskeleton through a more efficient recruitment and stability of endogenous Myo19 in the mitochondrial membrane. | 29311115 |
| Type | IDs |
|---|---|
| Synonymous | Arht2, Miro2 |
| Gene |
UniProtKB-ID:
MIRO2_MOUSE
UniprotKB:
Q8JZN7
UniParc:
UPI00000E76C5
EMBL:
AY311390,
BC029777,
BC034062
Ensembl:
ENSMUSG00000025733
KO:
mmu:214952
|
| Nucleutide sequences |
EMBL-CDS:
AAH34062.1,
AAP78906.1,
AAH29777.1
Ensembl_TRS:
ENSMUST00000043897
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000044639
RefSeq:
NP_666111.1,
NP_001351879.1
|
| Others |
UniRef100:
UniRef100_Q8JZN7
UniRef90:
UniRef90_Q8JZN7
UniRef50:
UniRef50_Q8IXI2
UniGene:
Mm.40907,
Mm.490420
CCDS:
CCDS37505.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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