Scgn - secretagogin, EF-hand calcium binding protein-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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214189 Scgn

基因描述

Type	Description
Definition	secretagogin, EF-hand calcium binding protein

研究结论

Date	Results	Publications
2021-01-02 12:48:00	The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1.	31918914
2020-07-04 11:58:00	Secretagogin physically binds alpha-synuclein and rescues it from detrimental fibrillation.	31617346
2019-06-01 10:21:00	Secretagogin prevents Pdx1 degradation through proteasome inactivation. Thas, secretagogin controls a transcriptional program required for beta cell specification.	29910119
2018-04-14 10:25:00	Secretagogin-dependent MMP2 release from neurons regulates neuroblast migration.	28223495
2017-05-20 11:45:00	Secretagogin affects insulin secretion in pancreatic beta-cells by regulating actin dynamics and focal adhesion	27095850

名称对应

Type	IDs
Gene	UniProtKB-ID: SEGN_MOUSE UniprotKB: Q91WD9 UniParc: UPI0000021B9D EMBL: BC016093 Ensembl: ENSMUSG00000021337 KO: mmu:214189
Nucleutide sequences	EMBL-CDS: AAH16093.1 Ensembl_TRS: ENSMUST00000021770
Protein sequencees	Ensembl_PRO: ENSMUSP00000021770 RefSeq: NP_663374.1, XP_006516701.1
Others	UniRef100: UniRef100_Q91WD9 UniRef90: UniRef90_Q6R556 UniRef50: UniRef50_O76038 UniGene: Mm.255667 CCDS: CCDS26375.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
31918914	The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1. Mol Metab Andrew D Biancolin , Alexandre Martchenko , Emilia Mitova , Patrick Gurges , Everan Michalchyshyn , Jennifer A Chalmers , Alessandro Doria , Josyf C Mychaleckyj , Alice E Adriaenssens , Frank Reimann , Fiona M Gribble , Manuel Gil-Lozano , Brian J Cox , Patricia L Brubaker	2020-01-01	-
31796600	Brain-wide genetic mapping identifies the indusium griseum as a prenatal target of pharmacologically unrelated psychostimulants. Proc. Natl. Acad. Sci. U.S.A. Janos Fuzik , Sabah Rehman , Fatima Girach , Andras G Miklosi , Solomiia Korchynska , Gloria Arque , Roman A Romanov , JÃ¡nos Hanics , Ludwig Wagner , Konstantinos Meletis , Yuchio Yanagawa , Gabor G Kovacs , AlÃ¡n AlpÃ¡r , Tomas G M HÃ¶kfelt , Tibor Harkany	2019-12-17	-
31617346	Secretagogin Binding Prevents Î±-Synuclein Fibrillation. Biochemistry Amrutha H Chidananda , Anand Kumar Sharma , Radhika Khandelwal , Yogendra Sharma	2019-11-19	-
31144035	Secretagogin expression in the vertebrate brainstem with focus on the noradrenergic system and implications for Alzheimer's disease. Brain Struct Funct PÃ©ter Zahola , JÃ¡nos Hanics , Anna PintÃ©r , ZoltÃ¡n MÃ¡tÃ© , Anna GÃ¡spÃ¡rdy , ZsÃ³fia Hevesi , Diego Echevarria , Csaba Adori , Swapnali Barde , BeÃ¡ta TÃ¶rÅcsik , Ferenc ErdÃ©lyi , GÃ¡bor SzabÃ³ , Ludwig Wagner , Gabor G Kovacs , Tomas HÃ¶kfelt , Tibor Harkany , AlÃ¡n AlpÃ¡r	2019-07-01	-
29910119	Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for Î² cell specification. Mol Metab Katarzyna Malenczyk , Edit Szodorai , Robert Schnell , Gert Lubec , GÃ¡bor SzabÃ³ , Tomas HÃ¶kfelt , Tibor Harkany	2018-08-01	-
28449024	Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity. Cereb. Cortex Chandrasekhar S Raju , Julien Spatazza , Amelia Stanco , Phillip Larimer , Shawn F Sorrells , Kevin W Kelley , Cory R Nicholas , Mercedes F Paredes , Jan H Lui , Andrea R Hasenstaub , Arnold R Kriegstein , Arturo Alvarez-Buylla , John L Rubenstein , Michael C Oldham	2018-06-01	-
28760865	Dystroglycan Maintains Inner Limiting Membrane Integrity to Coordinate Retinal Development. J. Neurosci. Reena Clements , Rolf Turk , Kevin P Campbell , Kevin M Wright	2017-08-30	-
28637794	A TRPV1-to-secretagogin regulatory axis controls pancreatic Î²-cell survival by modulating protein turnover. EMBO J. Katarzyna Malenczyk , Fatima Girach , Edit Szodorai , Petter Storm , Ãsa Segerstolpe , Giuseppe Tortoriello , Robert Schnell , Jan Mulder , Roman A Romanov , ErzsÃ©bet BorÃ³k , Fabiana Piscitelli , Vincenzo Di Marzo , GÃ¡bor SzabÃ³ , Rickard Sandberg , Stefan Kubicek , Gert Lubec , Tomas HÃ¶kfelt , Ludwig Wagner , Leif Groop , Tibor Harkany	2017-07-14	-
28223495	Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration. Proc. Natl. Acad. Sci. U.S.A. JÃ¡nos Hanics , Edit Szodorai , Giuseppe Tortoriello , Katarzyna Malenczyk , Erik Keimpema , Gert Lubec , ZsÃ³fia Hevesi , Mirjam I Lutz , MÃ¡rk Kozsurek , Zita PuskÃ¡r , Zsuzsanna E TÃ³th , Ludwig Wagner , GÃ¡bor G KovÃ¡cs , Tomas G M HÃ¶kfelt , Tibor Harkany , AlÃ¡n AlpÃ¡r	2017-03-07	-
28199486	Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar Interneurons in the Mouse Retina. Invest. Ophthalmol. Vis. Sci. Ko Uoon Park , Grace Randazzo , Kenneth L Jones , Joseph A Brzezinski	2017-02-01	-

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