| Type | Description |
|---|---|
| Definition | HNF1 homeobox B |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:35:00 | Hepatocyte nuclear factor 1beta suppresses canonical Wnt signaling through transcriptional repression of lymphoid enhancer-binding factor 1. | 33453998 |
| 2020-07-25 11:38:00 | Study shows how Hnf1b inactivation in pancreatic ductal cells leads to chronic pancreatitis, neoplasia, and potentiates pancreatic intraepithelial neoplasia formation. This shows a cause of pancreatitis and identifies Hnf1b as a potential tumor suppressor for pancreatic cancer. | 31229598 |
| 2020-05-02 12:47:00 | A function of HNF-1b in the regulation of canonical (beta-catenin-dependent) Wnt signaling in the kidney.HNF-1b and beta-catenin/LEF compete for binding to a beta-catenin/lymphoid enhancer binding factor site overlapping with an HNF-1b half-site. | 31712448 |
| 2019-09-21 10:46:00 | Ablation of HNF-1beta in renal epithelial cells leads to the activation of a Twist2-dependent transcriptional network that induces epithelial-mesenchymal transition and aberrant TGF-beta signaling, resulting in renal fibrosis through a cell-nonautonomous mechanism. | 30097458 |
| 2019-07-20 11:19:00 | HNF1beta is a transcriptional activator of the CaSR. | 29561186 |
| Type | IDs |
|---|---|
| Synonymous | HNF-1-beta, HNF-1B, HNF-1Beta, Hnf1beta, LFB3, Tcf-2, Tcf2, vHNF1 |
| Gene |
UniProtKB-ID:
HNF1B_MOUSE
UniprotKB:
P27889
UniParc:
UPI00000E893B,
UPI00000E67A9,
UPI0000191DDB,
UPI0000029522
EMBL:
AB008176,
AK004837,
BC025189,
AL669868,
AB008175,
AB008177,
AB052659,
X55842,
AB008174,
AK019258
Ensembl:
ENSMUSG00000020679
KO:
mmu:21410
|
| Nucleutide sequences |
EMBL-CDS:
BAB23604.1,
BAB60814.1,
BAB31632.2,
BAA77718.1,
CAA39358.1,
BAA77720.1,
BAA77719.1,
AAH25189.1,
BAA77721.1
Ensembl_TRS:
ENSMUST00000021016,
ENSMUST00000108114,
ENSMUST00000108113
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000103749,
ENSMUSP00000103748,
ENSMUSP00000021016
RefSeq:
XP_006532856.1,
XP_006532859.1,
NP_033356.2,
XP_006532857.1,
NP_001278198.1,
NP_001278197.1,
XP_006532854.1
|
| Others |
UniRef100:
UniRef100_P27889
UniRef90:
UniRef90_P27889
UniRef50:
UniRef50_P35680
UniGene:
Mm.7226
CCDS:
CCDS70271.1,
CCDS25179.1,
CCDS70272.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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