| Type | Description |
|---|---|
| Definition | T-box 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:30:00 | Stoichiometric optimization of Gata4, Hand2, Mef2c, and Tbx5 expression for contractile cardiomyocyte reprogramming. | 31628386 |
| 2020-07-11 10:22:00 | Mice homozygous for Tbx5 R264K showed compensated dilated cardiomyopathy. Thus, TBX5 R264K may have a significant pathogenic role in some cardiomyopathy patients independently of T-box domain pathway. | 32236096 |
| 2020-04-04 12:58:00 | These results directly link transcriptional control of SERCA2 activity, depressed sarcoplasmic reticulum Ca(2+) sequestration, enhanced trans-sarcolemmal calcium fluxes, and atrial fibrillation, establishing a mechanism underlying the genetic basis for a Ca(2+)-dependent pathway for atrial fibrillation risk in Tbx5-deficient mice. | 30896405 |
| 2019-04-27 10:27:00 | Normal downregulation of the definitive arterial pole progenitor cell program in the posterior of the Second Heart Field (SHF) is dependent on both Tbx1 and Tbx5. Furthermore, retinoic acid (RA) signaling is required for Tbx5 activation in Tbx1-positive cells and blocking RA signaling at the time of Tbx5 activation results in atrioventricular septal defects at fetal stages. | 30016433 |
| 2018-08-18 12:09:00 | Enrichment of induced cardiomyocytes derived from mouse fibroblasts can be achieved by reprogramming with cardiac transcription factors, Gata4, MEF2c, Tbx5, and Hand2. | 29257325 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
TBX5_MOUSE,
Q5CZX7_MOUSE
UniprotKB:
P70326,
Q5CZX7
UniParc:
UPI00000215A5
EMBL:
U57330,
AF140427,
BC090639
Ensembl:
ENSMUSG00000018263
KO:
mmu:21388
|
| Nucleutide sequences |
EMBL-CDS:
AAC53109.1,
AAF00112.1,
AAH90639.1
Ensembl_TRS:
ENSMUST00000018407
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000018407
RefSeq:
XP_006530344.1,
XP_006530343.1,
XP_011246493.1,
XP_006530342.1,
NP_035667.1,
XP_006530346.1,
XP_006530345.1
|
| Others |
UniRef100:
UniRef100_P70326
UniRef90:
UniRef90_P70326
UniRef50:
UniRef50_P70326
UniGene:
Mm.103636
CCDS:
CCDS19615.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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