| Type | Description |
|---|---|
| Definition | TRAF family member-associated Nf-kappa B activator |
| Date | Results | Publications |
|---|---|---|
| 2020-06-06 13:37:00 | Findings suggest that the cortical neuroimmune regulator TANK is involved in cortical aversive emotion processing and related control of alcohol drinking behavior. A tank knock out mouse model suggests a role of TANK in alcohol drinking, anxiety-related behavior, as well as alcohol exposure induced activation of insular cortex NF-kappaB. | 30721969 |
| 2013-07-27 10:44:00 | TANK is expressed in DRG neurons. TANK is increased by peripheral nerve injury. the regulation of TANK expression is, at least in part, controlled by the injury-associated transcription factor Sox11. | 23201825 |
| 2013-05-04 11:37:00 | Tank, whose expression is increased during osteoclastogenesis, inhibits osteoclast formation, activity and survival, by regulating NF-kappaB activity and c-FLIP expression. | 23139637 |
| 2012-11-03 11:40:00 | TANK is critical for osteoclastogenesis by regulating NF-kappaB, and is also important for proper bone remodeling. | 22773835 |
| 2011-12-17 11:40:00 | role for TANK in enabling the canonical IKKs and the IKK-related kinases to regulate each other, which is required to limit the strength of TLR signaling and ultimately, prevent autoimmunity | 21949249 |
| Type | IDs |
|---|---|
| Synonymous | C86182, E430026L09Rik, I-TRAF |
| Gene |
UniProtKB-ID:
TANK_MOUSE,
Q3TNB4_MOUSE,
Q3UGW0_MOUSE,
A2AR76_MOUSE,
Q8C2D3_MOUSE
UniprotKB:
P70347,
Q3TNB4,
Q3UGW0,
A2AR76,
Q8C2D3
UniParc:
UPI000002B4B8,
UPI0000027035,
UPI00000EA083,
UPI0000D777D3,
UPI000002B4B9,
UPI00005AC6C2,
UPI00005B214A,
UPI000002B4BA
EMBL:
AK088817,
AK147727,
AK165420,
AL928859,
U51907,
U59864,
AL845291
Ensembl:
ENSMUSG00000064289
KO:
mmu:21353
|
| Nucleutide sequences |
EMBL-CDS:
AAC52781.1,
AAB02204.1,
BAE38175.1,
BAE28097.1,
BAC40592.1
Ensembl_TRS:
ENSMUST00000078074,
ENSMUST00000112501,
ENSMUST00000112502,
ENSMUST00000112495
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000077219,
ENSMUSP00000108120,
ENSMUSP00000108121,
ENSMUSP00000108114
RefSeq:
XP_036016123.1,
XP_036016130.1,
NP_001342197.1,
NP_001342196.1,
XP_017172402.1,
XP_036016126.1,
XP_036016125.1,
NP_001157543.1,
XP_036016129.1,
NP_001157544.1,
NP_001361596.1,
NP_001365851.1,
XP_036016124.1,
XP_036016128.1,
NP_035659.1,
XP_036016127.1
|
| Others |
UniRef100:
UniRef100_Q3TNB4,
UniRef100_A2AR76,
UniRef100_Q3UGW0,
UniRef100_P70347
UniRef90:
UniRef90_P70347
UniRef50:
UniRef50_Q92844
UniGene:
Mm.244393
CCDS:
CCDS16061.1,
CCDS50592.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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