| Type | Description |
|---|---|
| Definition | transforming, acidic coiled-coil containing protein 3 |
| Date | Results | Publications |
|---|---|---|
| 2017-09-09 11:59:00 | Tacc3 is required for the proper mitosis of Apc-deficient ISCs, and its disruption significantly attenuated the expansion of the crypt domain. In vivo analysis of corresponding mutant mice demonstrated that Tacc3 disruption led to a significant decrease in tumor number and prolonged survival. | 27157623 |
| 2014-03-22 11:40:00 | Aurora-A kinase does not regulate TACC3-chTOG complex formation, indicating that Aurora-A solely functions as a recruitment factor for the TACC3-chTOG complex to centrosomes and proximal mitotic spindles. | 24273164 |
| 2013-11-30 12:36:00 | The TACC3 and clathrin were interdependent for spindle recruitment, having to interact in order for either to be recruited to the spindle. | 23918938 |
| 2012-11-17 10:24:00 | DOCK7 interaction with TACC3 controls interkinetic nuclear migration and the genesis of neurons from radial glial progenitor cells during cortical development | 22842144 |
| 2012-03-03 10:05:00 | results show that Tacc3 is a vulnerable component of the spindle assembly in lymphoma cells and is a promising cancer chemotherapy target | 21685933 |
| Type | IDs |
|---|---|
| Synonymous | Aint, C86661, Eric1 |
| Gene |
UniProtKB-ID:
Q99LH8_MOUSE,
Q6NV52_MOUSE
UniprotKB:
Q99LH8,
Q6NV52
UniParc:
UPI000023C828,
UPI0000027C8A
EMBL:
AC162898,
BC003252,
BC068314,
AK145556,
BC066184
Ensembl:
ENSMUSG00000037313
KO:
mmu:21335
|
| Nucleutide sequences |
EMBL-CDS:
AAH03252.1,
AAH66184.1,
AAH68314.1,
BAE26507.1
Ensembl_TRS:
ENSMUST00000074849,
ENSMUST00000114426,
ENSMUST00000079534
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000074394,
ENSMUSP00000078491,
ENSMUSP00000110069
RefSeq:
XP_036020876.1,
XP_006503895.1,
XP_006503898.1,
XP_011239018.1,
XP_030110212.1,
XP_030110209.1,
XP_030110210.1,
NP_001035525.1,
NP_001297470.1,
XP_011239017.1,
XP_030110211.1
|
| Others |
UniRef100:
UniRef100_Q99LH8,
UniRef100_Q6NV52
UniRef90:
UniRef90_Q9JJ11
UniRef50:
UniRef50_Q9JJ11
UniGene:
Mm.379024
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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