| Type | Description |
|---|---|
| Definition | solute carrier family 39 (zinc transporter), member 14 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-25 11:25:00 | This study provides evidence in an integrative animal model that basolaterally localized ZIP14 regulates Mn excretion and detoxification and that deletion of intestinal ZIP14 leads to systemic and brain Mn accumulation, providing robust evidence for the indispensable role of intestinal ZIP14 in Mn excretion. | 32003605 |
| 2020-02-29 11:26:00 | Lack of ZIP14 severely impaired basolateral-to-apical (secretory) manganese transport and strongly enhanced manganese transport in the apical-to-basolateral (absorptive) direction. Mechanistic studies provided evidence that ZIP14 restricts manganese transport in the absorptive direction via direct basolateral reuptake of freshly absorbed manganese. | 31028174 |
| 2019-05-18 11:08:00 | These results highlight a previously unrecognized role for altered zinc homeostasis in metastatic cancer-induced muscle wasting and implicate ZIP14 as a therapeutic target for its treatment. | 29875463 |
| 2018-07-28 11:26:00 | This study concludes that SLC39A14 is essential for efficient Mn uptake by the liver and pancreas, and its deficiency results in impaired Mn excretion and accumulation of the metal in other tissues. | 29437953 |
| 2018-06-30 10:56:00 | Data indicate SLC39A14 (ZIP14) as a regulator of bone homeostasis, and that manipulating ZIP14 might be a therapeutic strategy for bone diseases. | 29621230 |
| Type | IDs |
|---|---|
| Synonymous | FAD-123, ZIP-14, Zip14, fad123 |
| Gene |
UniProtKB-ID:
S39AE_MOUSE
UniprotKB:
Q75N73
UniParc:
UPI0000021DEA,
UPI00001E922E
EMBL:
AK122197,
BC021530,
AC025669,
AB177995
Ensembl:
ENSMUSG00000022094
KO:
mmu:213053
|
| Nucleutide sequences |
EMBL-CDS:
AAH21530.1,
BAD16742.1,
BAC65479.2
Ensembl_TRS:
ENSMUST00000022688,
ENSMUST00000068044,
ENSMUST00000152067
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000022688,
ENSMUSP00000119040,
ENSMUSP00000066108
RefSeq:
NP_001128624.1,
XP_030103573.1,
XP_006518849.1,
XP_006518854.1,
XP_030103577.1,
XP_030103572.1,
NP_659057.2,
XP_006518851.1,
XP_006518852.1,
XP_030103576.1,
XP_006518850.1,
XP_030103574.1,
XP_030103575.1,
NP_001128623.1
|
| Others |
UniRef100:
UniRef100_Q75N73
UniRef90:
UniRef90_Q75N73
UniRef50:
UniRef50_Q75N73
UniGene:
Mm.270647
CCDS:
CCDS49536.1,
CCDS36969.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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