| Type | Description |
|---|---|
| Definition | PDZ and LIM domain 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:37:00 | PDLIM2 protects articular chondrocytes from lipopolysaccharide-induced apoptosis, degeneration and inflammatory injury through down-regulation of nuclear factor (NF)-kappaB signaling. | 32805696 |
| 2020-03-07 11:08:00 | By 19 months of age, all PDLIM2-/- mice, compared to less than 10% of wild-type (WT) mice, spontaneously developed tumors. 50% of them were lung tumors. PDLIM2 -/- mice were also more sensitive to K-RasG12D-induced lung tumorigenesis | 31757943 |
| 2018-12-22 12:33:00 | Reducing NF-kappaB activation attenuates PDLIM2 deficiency-exacerbated inflammation and dyslipidemia in Palmitate -treated primary hepatocytes. | 29852170 |
| 2017-06-10 10:12:00 | Klotho can modulate inflammation via PDLIM2/NF-kappaB p65 pathway in cyclosporine A-induced nephropathy. | 28315683 |
| 2012-04-21 11:29:00 | Deficiency in PDLIM2 resulted in the accumulation of in the nucleus, enhanced the extent of TH17 cell differentiation, and exacerbated granuloma formation. | 22155789 |
| Type | IDs |
|---|---|
| Synonymous | 4732462F18Rik, Slim |
| Gene |
UniProtKB-ID:
PDLI2_MOUSE
UniprotKB:
Q8R1G6
UniParc:
UPI0000021DE6
EMBL:
BC024556
Ensembl:
ENSMUSG00000022090
KO:
mmu:213019
|
| Nucleutide sequences |
EMBL-CDS:
AAH24556.1
Ensembl_TRS:
ENSMUST00000022681,
ENSMUST00000153735
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000116200,
ENSMUSP00000022681
RefSeq:
XP_030103571.1,
NP_666090.1,
XP_006518846.1,
XP_030103570.1,
NP_001240665.1,
XP_036014427.1
|
| Others |
UniRef100:
UniRef100_Q8R1G6
UniRef90:
UniRef90_Q6AYD6
UniRef50:
UniRef50_Q6AYD6
UniGene:
Mm.283968
CCDS:
CCDS27248.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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