| Type | Description |
|---|---|
| Definition | eukaryotic translation termination factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-01 10:10:00 | eRF1 accumulates within elaborate nuclear envelope invaginations in patient induced pluripotent stem cell (iPSC) neurons and postmortem tissue and mediates a protective shift from protein translation to nonsense-mediated decay -dependent mRNA degradation. | 32059759 |
| 2020-03-28 12:47:00 | We show that knockdown of human XRN1, CNOT6 and ETF1 genes in HepG2 cells led to significant alteration in stability of specific mRNAs, alterations in half-life were inversely associated with transcription rates, mostly not resulting in changes in abundance | 31116665 |
| 2018-09-22 11:27:00 | Report molecular dynamics free energy calculations on termination complexes, where relative eRF1 binding free energies to different cognate and near-cognate codons are evaluated. The simulations show a high and uniform discrimination against the near-cognate codons, that differ from the cognate ones by a single nucleotide, and reveal the structural mechanisms behind the precise decoding by eRF1. | 29127299 |
| 2016-12-17 12:07:00 | The GTS loop forms a switch that is key for the multiple codon recognition capability of eRF1. | 26725946 |
| 2016-06-11 10:14:00 | New information has been presented on architecture of the eRF1 binding site on mammalian ribosome at various translation termination steps and on conformational rearrangements induced by binding of the release factors. | 26655225 |
| Type | IDs |
|---|---|
| Synonymous | D5S1995, ERF, ERF1, RF1, SUP45L1, TB3-1 |
| Gene |
UniProtKB-ID:
ERF1_HUMAN,
B7Z7P8_HUMAN
UniprotKB:
P62495,
B7Z7P8
UniParc:
UPI00001110CB,
UPI0001915178,
UPI00000725A9
EMBL:
BC088358,
BC014269,
BT007374,
AK312510,
CH471062,
AC011385,
AK302364,
U90176,
X81625,
AF095901,
AC113403,
M75715
Ensembl:
ENSG00000120705
KO:
hsa:2107
|
| Nucleutide sequences |
EMBL-CDS:
EAW62131.1,
EAW62132.1,
AAD43966.1,
AAH14269.1,
AAB49726.1,
CAA57281.1,
EAW62130.1,
BAG35411.1,
AAH88358.1,
AAP36038.1,
AAA36665.1,
BAH13684.1
Ensembl_TRS:
ENST00000360541,
ENST00000499810,
ENST00000503014
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000421288,
ENSP00000353741,
ENSP00000422203
RefSeq:
NP_001278903.1,
NP_001278904.1,
XP_016864710.1,
NP_001351089.1,
NP_001269114.1,
NP_004721.1,
NP_001243231.1
|
| Others |
UniRef100:
UniRef100_B7Z7P8,
UniRef100_P62495
UniRef90:
UniRef90_P62498,
UniRef90_P62495
UniRef50:
UniRef50_P62495
UniGene:
Hs.483494
CCDS:
CCDS75313.1,
CCDS4207.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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