| Type | Description |
|---|---|
| Definition | SH3 and multiple ankyrin repeat domains 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:57:00 | Identification of a novel Shank2 transcriptional variant in Shank2 knockout mouse model of autism spectrum disorder. | 32252796 |
| 2020-10-10 13:03:00 | Impaired actin dynamics and suppression of Shank2-mediated spine enlargement in cortactin knockout mice. | 31990031 |
| 2019-10-05 11:53:00 | Mice lacking Shank2 in GABAergic inhibitory neurons display social communication deficits, repetitive self-grooming, and mild hyperactivity. These behavioral changes were associated with distinct changes in hippocampal and striatal synaptic transmission. | 29572432 |
| 2019-01-26 10:56:00 | Study shows defective synapse maturation and enhanced synaptic plasticity in shank2 Deltaex7(-/-) mice. Findings add to the diversity of synaptic phenotypes in neurodevelopmental disorders and further support the supposed existence of "modifier genes" in the expression and inheritance of autism spectrum disorders. | 30023428 |
| 2018-09-08 11:27:00 | The results indicate that SHANK2 is crucial for parallel fiber-Purkinje cell long-term potentiation, but not long-term depression. In addition, SHANK2 is important for intrinsic plasticity of neuronal excitability. | 27581745 |
| Type | IDs |
|---|---|
| Synonymous | ProSAP1, mKIAA1022 |
| Gene |
UniProtKB-ID:
SHAN2_MOUSE,
D3Z5K8_MOUSE
UniprotKB:
Q80Z38,
D3Z5K8
UniParc:
UPI0000D66655,
UPI00001E426F,
UPI0000605B2D,
UPI0000605B2E
EMBL:
AC140268,
AB099695,
AC127546,
AK139360,
AC124520,
AK220363,
AC152166,
BC167171
Ensembl:
ENSMUSG00000037541
KO:
mmu:210274
|
| Nucleutide sequences |
EMBL-CDS:
BAC58120.1,
BAD90424.1,
AAI67171.1,
BAE23976.1
Ensembl_TRS:
ENSMUST00000146006,
ENSMUST00000105900,
ENSMUST00000105902
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000146440,
ENSMUSP00000101520,
ENSMUSP00000101522
RefSeq:
XP_030098182.1,
XP_006508582.1,
XP_006508592.1,
NP_001106844.3,
XP_006508590.1,
XP_036008764.1,
XP_006508598.1,
XP_030098186.1,
XP_006508597.1,
XP_017177581.1,
XP_006508594.1,
XP_036008762.1,
XP_006508589.1,
XP_017177580.1,
XP_030098185.1,
XP_006508588.1,
XP_006508596.1,
XP_030098189.1,
XP_036008763.1,
XP_030098187.1,
XP_006508593.1,
XP_030098188.1,
NP_001074839.3,
XP_006508584.1,
XP_006508591.1,
XP_006508585.1,
XP_006508587.1,
XP_006508586.1,
XP_006508583.1,
XP_006508599.1,
XP_030098183.1,
XP_006508595.1
|
| Others |
UniRef100:
UniRef100_D3Z5K8,
UniRef100_Q80Z38
UniRef90:
UniRef90_D3Z5K8,
UniRef90_Q80Z38
UniRef50:
UniRef50_Q9QX74-7,
UniRef50_Q80Z38
UniGene:
Mm.483624
CCDS:
CCDS85484.1,
CCDS40201.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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