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209334 Gen1

209334

Gen1

GEN1, Holliday junction 5' flap endonuclease

protein-coding

Mus musculus

基因描述

Type Description
Definition GEN1, Holliday junction 5' flap endonuclease

研究结论

Date Results Publications
2019-02-16 12:23:00 Results revealed an unidentified role of GEN1 in kidney development and suggested its contribution to congenital anomalies of the kidney and urinary tract. 29483821
2016-12-31 10:37:00 Study found that a Gen1 mutation alone did not affect DNA repair or meiotic recombination in mice; it caused synthetic lethality when combined with Eme1 mutations at an early embryonic stage. Also, combination of Gen1 and Eme1 mutations makes embryonic fibroblasts more sensitive to DNA damage & mice less capable of meiotic recombination. These results indicate that Gen1 and Eme1 are functionally redundant in mice. 27383418
2015-07-25 10:09:00 The results suggest that GEN1 may play an important role in the development of mammary gland. 24980922

名称对应

Type IDs
Synonymous 5830483C08Rik
Gene
UniProtKB-ID: GEN_MOUSE
UniprotKB: Q8BMI4
UniParc: UPI00001C4D84, UPI00016277B2
EMBL: BC138158, AK031077, AK158255, BC138157, BC090653, AK030995
Ensembl: ENSMUSG00000051235
KO: mmu:209334
Nucleutide sequences
EMBL-CDS: BAE34428.1, AAH90653.1, AAI38158.1, BAC27242.1, BAC27207.1, AAI38159.1
Ensembl_TRS: ENSMUST00000166117
Protein sequencees
Ensembl_PRO: ENSMUSP00000132098
RefSeq: XP_006515104.1, NP_796305.3, XP_011242153.1, XP_006515105.1, XP_017170499.1, XP_006515103.1, XP_006515102.1, XP_011242154.1
Others
UniRef100: UniRef100_Q8BMI4
UniRef90: UniRef90_Q8BMI4
UniRef50: UniRef50_Q17RS7
UniGene: Mm.215295
CCDS: CCDS36403.1

全选

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研究热度

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