| Type | Description |
|---|---|
| Definition | giant axonal neuropathy |
| Date | Results | Publications |
|---|---|---|
| 2017-09-30 11:59:00 | We demonstrate that gigaxonin is crucial for ubiquitin-proteasomal degradation of neuronal Intermediate filaments. Moreover,Intermediate filaments accumulation impairs mitochondrial motility and is associated with metabolic and oxidative stress | 27000625 |
| 2013-07-06 10:34:00 | gigaxonin is a major factor in the degradation of cytoskeletal intermediate filaments | 23585478 |
| 2012-05-19 11:03:00 | GAN variants are identified in brain sections of mutant mice with giant axonal neuropathy. | 19782434 |
| 2010-01-21 00:00:00 | At 6 months of age the Gigaxonin-knockout(Deltaexon1;Deltaexon1) mice exhibit a modest hind limb muscle atrophy, a 10% decrease of muscle innervation and a 27% axonal loss in the L5 ventral roots. | 18680552 |
| 2010-01-21 00:00:00 | results identify gigaxonin as a ubiquitin scaffolding protein that controls MAP1B-LC degradation, and provide insight into the molecular mechanisms underlying human neurodegenerative disorders | 16227972 |
| Type | IDs |
|---|---|
| Synonymous | A330045G18, gigaxonin |
| Gene |
UniProtKB-ID:
GAN_MOUSE
UniprotKB:
Q8CA72
UniParc:
UPI0000512117
EMBL:
AC121116,
BC112432,
AK039455
Ensembl:
ENSMUSG00000052557
KO:
mmu:209239
|
| Nucleutide sequences |
EMBL-CDS:
BAC30353.1,
AAI12433.1
Ensembl_TRS:
ENSMUST00000064488
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000070168
RefSeq:
NP_001074620.1
|
| Others |
UniRef100:
UniRef100_Q8CA72
UniRef90:
UniRef90_Q8CA72
UniRef50:
UniRef50_Q8CA72
UniGene:
Mm.132992
CCDS:
CCDS40490.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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