| Type | Description |
|---|---|
| Definition | dedicator of cyto-kinesis 3 |
| Date | Results | Publications |
|---|---|---|
| 2018-05-19 10:55:00 | Common features in both affected individuals include severe developmental disability, ataxic gait, and severe hypotonia, which recapitulates the Dock3 knockout mouse phenotype. We show that complete DOCK3 deficiency in humans leads to developmental disability with significant hypotonia and gait ataxia, probably due to abnormal axonal development | 28195318 |
| 2015-09-12 11:08:00 | Dock3 may be a therapeutic target for demyelinating disorders including optic neuritis. | 25165881 |
| 2015-06-20 11:27:00 | Overexpression of Dock3 and pharmacological interruption of p38 have synergistic effects for both neuroprotection and axon regeneration, thus combined application may be beneficial for the treatment of ONI. | 25172145 |
| 2014-08-23 10:53:00 | Skeletal muscle-specific miR-486 overexpression in Dmdmdx-5Cv animals decreased levels of DOCK3, reduced PTEN expression, and subsequently increased levels of phosphorylated AKT, which resulted in an overall beneficial effect. | 24789910 |
| 2014-04-05 13:30:00 | These results suggest that Dock3 overexpression prevents glaucomatous retinal degeneration by suppressing both NR2B-mediated glutamate neurotoxicity and oxidative stress. | 23852370 |
| Type | IDs |
|---|---|
| Synonymous | MOCA, PBP, mKIAA0299 |
| Gene |
UniProtKB-ID:
F8VPQ1_MOUSE,
Q3UHH9_MOUSE
UniprotKB:
F8VPQ1,
Q3UHH9
UniParc:
UPI00001F7E24,
UPI00005AC646
EMBL:
AC147636,
AK147385,
AL672070,
AC121608,
AC123065,
AL672208
Ensembl:
ENSMUSG00000039716
KO:
mmu:208869
|
| Nucleutide sequences |
EMBL-CDS:
BAE27878.1
Ensembl_TRS:
ENSMUST00000044532
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000047652
RefSeq:
XP_011241175.1,
XP_011241173.1,
XP_006511754.1,
XP_030100037.1,
XP_017168749.1,
NP_700462.2,
XP_011241174.1,
XP_011241171.1,
XP_011241177.1,
XP_030100038.1,
XP_036010664.1,
XP_011241172.1
|
| Others |
UniRef100:
UniRef100_F8VPQ1,
UniRef100_Q3UHH9
UniRef90:
UniRef90_Q8IZD9,
UniRef90_Q3UHH9
UniRef50:
UniRef50_A0A3Q1M3N9,
UniRef50_Q8IZD9
UniGene:
Mm.150259
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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