| Type | Description |
|---|---|
| Definition | aurora kinase C |
| Date | Results | Publications |
|---|---|---|
| 2019-10-26 11:37:00 | in the absence of AURKC, AURKA localizes to chromosomes in a CPC-dependent manner. These data suggest that AURKC prevents AURKA from localizing to chromosomes by competing for CPC binding. This competition is important for adequate spindle length to support meiosis I. There is also a unique requirement for AURKB to negatively regulate AURKC to prevent aneuploidy. | 30415701 |
| 2018-04-21 10:12:00 | findings demonstrate that maternal RNAs regulate AURKC localization and activity in mouse oocytes | 28575288 |
| 2017-11-25 14:05:00 | The high sequence similarity among the AURK family members has made discerning the individual kinase functions in meiosis challenging. Technical limitations in specifically targeting AURKB or AURKC using small-molecule inhibitors and compensatory abilities in single-knockout animals add to this challenge...proper regulation of AURKA expression is crucial for spindle formation in meiosis | 28359584 |
| 2017-09-23 12:55:00 | Three of these mutations AURKC c.144delC (AURKC p.L49Wfs22), AURKC c.686G > A (AURKC p.C229Y) and AURKC c.744C > G (AURKC p.Y248*) are the focus of this study. AURKC p.L49Wfs22 is a loss-of-function mutant that perturbs localization of the chromosomal passenger complex (CPC), AURKC p.C229Y is a hypomorph that cannot fully support cell-cycle progression, and AURKC p.Y248* fails to support chromosome segregation. | 27106102 |
| 2017-08-05 12:57:00 | These data uncover a role for haspin as a regulator of bipolar spindle assembly by regulating AURKC function at acentriolar microtubule-organizing centers in oocytes. | 27562071 |
| Type | IDs |
|---|---|
| Synonymous | AIE1, AIK3, ARK-3, IAK3, Stk13 |
| Gene |
UniProtKB-ID:
AURKC_MOUSE,
E9QL04_MOUSE,
Q497X5_MOUSE
UniprotKB:
O88445,
E9QL04,
Q497X5
UniParc:
UPI0000231644,
UPI0000F0888D,
UPI0000574FBA
EMBL:
BC100337,
AC152418,
AF195272,
BC064780,
AF054620
Ensembl:
ENSMUSG00000070837
KO:
mmu:20871
|
| Nucleutide sequences |
EMBL-CDS:
AAH64780.1,
AAF25838.1,
AAC25954.1,
AAI00338.1
Ensembl_TRS:
ENSMUST00000207711,
ENSMUST00000208049,
ENSMUST00000086248
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000147207,
ENSMUSP00000146450,
ENSMUSP00000083426
RefSeq:
NP_001074435.1,
XP_006539760.1,
XP_017177568.1,
NP_065597.2,
NP_001074434.1,
XP_006539764.1
|
| Others |
UniRef100:
UniRef100_O88445
UniRef90:
UniRef90_O88445
UniRef50:
UniRef50_O70126
UniGene:
Mm.261572
CCDS:
CCDS85211.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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