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208677 Creb3l3

208677

Creb3l3

cAMP responsive element binding protein 3-like 3

protein-coding

Mus musculus

基因描述

Type Description
Definition cAMP responsive element binding protein 3-like 3

研究结论

Date Results Publications
2021-02-27 13:54:00 Synergistic regulation of hepatic Fsp27b expression by HNF4alpha and CREBH. 32553626
2021-02-27 13:52:00 Hepatocyte CREBH deficiency aggravates inflammatory liver injury following chemokine-dependent neutrophil infiltration through upregulation of NF-kappaB p65 in mice. 31797000
2020-05-30 12:59:00 CREBH is a major transcriptional regulator of hepatic autophagy and lysosomal biogenesis in response to nutritional or circadian signals. Under unfed or during energy-demanding phases of the circadian cycle, CREBH is activated to drive expression of key enzymes or regulators in autophagosome formation or autophagic process. It interacts with PPARalpha) and PPARgamma coactivator 1alpha. It acts a circadian-dependent man... 30912978
2019-10-05 10:58:00 This study not only establishes the importance of Sel1L-Hrd1 ERAD in the liver in the regulation of systemic energy metabolism, but also reveals a novel hepatic "ERAD-Crebh-Fgf21" axis directly linking ER protein turnover to gene transcription and systemic metabolic regulation. 30389665
2019-10-05 10:58:00 HRD1-ERAD catalyzes polyubiquitin conjugation onto CREBH at lysine 294 for its proteasomal degradation, bridging a multi-organ crosstalk in regulating growth, circadian behavior, and female fertility through regulating the CREBH-FGF21 regulatory axis. 30389664

名称对应

Type IDs
Synonymous BC010786, CREB-H, D10Bur1e
Gene
UniProtKB-ID: CR3L3_MOUSE
UniprotKB: Q91XE9
UniParc: UPI0000026B4E
EMBL: AK050186, AK077258, BC010786, BC028820, AF392874
Ensembl: ENSMUSG00000035041
KO: mmu:208677
Nucleutide sequences
EMBL-CDS: BAC34115.1, AAM73673.1, AAH10786.1, BAC36714.1, AAH28820.1
Ensembl_TRS: ENSMUST00000117422
Protein sequencees
Ensembl_PRO: ENSMUSP00000112836
RefSeq: NP_001369747.1, NP_663340.1
Others
UniRef100: UniRef100_Q91XE9
UniRef90: UniRef90_Q91XE9
UniRef50: UniRef50_Q91XE9
UniGene: Mm.294693
CCDS: CCDS24043.1

全选

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