| Type | Description |
|---|---|
| Definition | calcium/calmodulin-dependent protein kinase kinase 2, beta |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 12:01:00 | Inhibition of calcium/calmodulin-dependent protein kinase kinase (CaMKK) exacerbates impairment of endothelial cell and blood-brain barrier after stroke. | 30422362 |
| 2019-10-26 10:04:00 | the data presented here underscore the therapeutic potential of targeting CaMKK2 to promote efficacious and rapid healing of bone fractures and as a mechanism to strengthen normal bones. | 29314250 |
| 2019-06-29 11:07:00 | These data provide a valuable resource by establishing criteria for use of STO-609 to inhibit the in vivo functions of CaMKK2 and demonstrate its utility for treating metabolically-related hepatic disease. | 28924233 |
| 2019-06-22 11:13:00 | CaMKK2 is highly expressed within intratumoral myeloid cells in mouse models of breast cancer, and demonstrate its inhibition within myeloid cells suppresses tumor growth by increasing intratumoral accumulation of effector CD8(+) T cells and immune-stimulatory myeloid subsets. Tumor-associated macrophages isolated from Camkk2 KO mice expressed higher levels of chemokines involved in the recruitment of effector T cells. | 31164648 |
| 2018-06-09 10:56:00 | we demonstrated that systemic administration of the small molecule CaMKK2 inhibitor, STO-609, to irradiated mice enhanced Hematopoietic stem and progenitor cells (HSPCs)recovery and improved survival. These findings identify CaMKK2 as an important regulator of HSPC regeneration and demonstrate CaMKK2 inhibition is a novel approach to promoting hematopoietic recovery after BM injury. | 28981105 |
| Type | IDs |
|---|---|
| Synonymous | 6330570N16Rik, AW061083, mKIAA0787 |
| Gene |
UniProtKB-ID:
KKCC2_MOUSE
UniprotKB:
Q8C078
UniParc:
UPI0000470EBF,
UPI00000231F8,
UPI00001F26FC,
UPI00000E7CE3,
UPI00000EA2DE
EMBL:
BC023103,
AK122370,
AF453383,
AK044660,
AK031399,
AK032070
Ensembl:
ENSMUSG00000029471
KO:
mmu:207565
|
| Nucleutide sequences |
EMBL-CDS:
AAN75696.1,
AAH23103.1,
BAC27387.1,
BAC32023.1,
BAC65652.1,
BAC27681.1
Ensembl_TRS:
ENSMUST00000111668,
ENSMUST00000200109
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000143732,
ENSMUSP00000107297
RefSeq:
XP_006530294.1,
XP_030110166.1,
XP_030110167.1,
XP_036020841.1,
XP_006530299.1,
NP_663333.1,
XP_017176252.1,
XP_006530297.1,
NP_001186605.1,
XP_006530296.1,
XP_006530298.1,
XP_006530295.1,
XP_006530293.1
|
| Others |
UniRef100:
UniRef100_Q8C078
UniRef90:
UniRef90_Q8C078
UniRef50:
UniRef50_Q96RR4
UniGene:
Mm.289237
CCDS:
CCDS80395.1,
CCDS19655.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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