| Type | Description |
|---|---|
| Definition | spectrin beta, non-erythrocytic 2 |
| Date | Results | Publications |
|---|---|---|
| 2018-03-03 11:48:00 | Loss of EAAT4 accounts for the initial hyper-excitability of Purkinje cells lacking b-III spectrin and that loss of GLAST appears to work synergistically to worsen motor deficits. When levels of both EAAT4 and GLAST are compromised in b-III(-/-) mice, the proximal dendrites of Purkinje cells within the posterior cerebellum are the most vulnerable to degeneration. | 28173092 |
| 2016-07-16 11:13:00 | TGF-beta/beta2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome. | 26784546 |
| 2015-02-14 10:57:00 | Study shows a direct interaction between beta-III spectrin and erythroid ankyrin in the cerebellum and to demonstrate a critical role for beta-III spectrin in maintaining ankyrin R throughout the Purkinje cell dendritic tree. | 24603075 |
| 2012-01-14 10:45:00 | This study demonistrated that beta-III spectrin is critical for development of purkinje cell dendritic tree and spine morphogenesis. | 22090485 |
| 2011-01-01 10:54:00 | Beta-III spectrin mutation L253P interferes with binding to Arp1 and protein trafficking from the Golgi. | 20603325 |
| Type | IDs |
|---|---|
| Synonymous | Spnb3 |
| Gene |
UniProtKB-ID:
Q68FG2_MOUSE
UniprotKB:
Q68FG2
UniParc:
UPI00000210D3
EMBL:
BC079860,
AC147618
Ensembl:
ENSMUSG00000067889
KO:
mmu:20743
|
| Nucleutide sequences |
EMBL-CDS:
AAH79860.1
Ensembl_TRS:
ENSMUST00000008991
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000008991
RefSeq:
NP_067262.1
|
| Others |
UniRef100:
UniRef100_Q68FG2
UniRef90:
UniRef90_O15020
UniRef50:
UniRef50_O15020
UniGene:
Mm.329668
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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