| Type | Description |
|---|---|
| Definition | serine protease inhibitor, Kunitz type 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 10:20:00 | matriptase is a causative agent in the development of congenital tufting enteropathy (CTE) and may provide a new target for the treatment of CTE in individuals carrying SPINT2 mutation | 31628112 |
| 2020-05-09 10:23:00 | Hai-2 is an essential protease inhibitor for epithelial integrity, Epcam homeostasis and mucosal organization of the intestinal tract. | 30623107 |
| 2018-07-14 11:48:00 | Intestines of HAI-2 deficient mice showed altered expression of epithelial junctional proteins, including reduced levels of EpCAM, E-cadherin, occludin, claudin-1 and -7, as well as an increased level of claudin-4, indicating that the loss of HAI-2 compromises intestinal epithelial barrier function. | 29617460 |
| 2015-02-21 10:17:00 | HAI-1 regulates the activity of activated matriptase, whereas HAI-2 has an essential role in regulating prostasin-dependent matriptase zymogen activation. | 24962579 |
| 2013-01-05 10:17:00 | mutations in Prss8 restored placentation and normal development of HAI-1-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2-deficient embryos. | 22952456 |
| Type | IDs |
|---|---|
| Synonymous | AL024025, C76321, HAI-2 |
| Gene |
UniProtKB-ID:
SPIT2_MOUSE,
Q9D8Q8_MOUSE
UniprotKB:
Q9WU03,
Q9D8Q8
UniParc:
UPI000002B426,
UPI0000028C66,
UPI00000E8243,
UPI0000001846
EMBL:
AK007792,
BC003431,
AF099016,
AF099020,
AF099019,
BC026419
Ensembl:
ENSMUSG00000074227
KO:
mmu:20733
|
| Nucleutide sequences |
EMBL-CDS:
AAD22174.1,
AAD22172.1,
AAH03431.1,
AAD22173.1,
AAH26419.1,
BAB25258.1
Ensembl_TRS:
ENSMUST00000207601,
ENSMUST00000098604,
ENSMUST00000108236
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000103871,
ENSMUSP00000146580,
ENSMUSP00000096204
RefSeq:
NP_035594.1,
NP_001076017.1,
XP_017177561.1
|
| Others |
UniRef100:
UniRef100_Q9D8Q8,
UniRef100_Q9WU03
UniRef90:
UniRef90_Q9WU03-2,
UniRef90_Q9WU03
UniRef50:
UniRef50_Q9WU03,
UniRef50_Q9WU03-2
UniGene:
Mm.295230
CCDS:
CCDS39869.1,
CCDS39870.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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