| Type | Description |
|---|---|
| Definition | serine (or cysteine) peptidase inhibitor, clade A, member 1D |
| Date | Results | Publications |
|---|---|---|
| 2021-02-02 13:27:00 | CHOP and c-JUN up-regulate the mutant Z alpha1-antitrypsin, exacerbating its aggregation and liver proteotoxicity. | 32723872 |
| 2020-07-11 10:35:00 | Pi*ZZ individuals display minor alterations in serum iron parameters. Neither mild iron overload seen in these individuals nor the presence of HFE mutations (C282Y and H63D) constitute a major contributor to liver fibrosis development. | 31717526 |
| 2019-10-19 11:32:00 | calreticulin modulation may eliminate the toxic gain of function associated with aggregation of ZAAT in lung and liver, thus providing a potential new therapeutic approach to the treatment of AATD-related liver disease. | 30833329 |
| Type | IDs |
|---|---|
| Synonymous | AAT, AI118301, DOM-7, Dom1, Dom4, PI4, Serpina1a, Spi1-1, Spi1-4 |
| Gene |
UniProtKB-ID:
A1AT4_MOUSE,
A1AT1_MOUSE
UniprotKB:
Q00897,
P07758
UniParc:
UPI0000021AE6,
UPI0000003E4C
EMBL:
BC057989,
BC037007,
M75721,
AF481949,
BC011040,
BC057984,
M75718,
AH002568,
BC057982,
BC049970,
AK002537,
AK146619
Ensembl:
ENSMUSG00000071177,
ENSMUSG00000066366
KO:
mmu:20700,
mmu:20703
|
| Nucleutide sequences |
EMBL-CDS:
AAC28867.1,
BAB22173.1,
BAE27308.1,
AAH57989.1,
AAH37007.2,
AAH57984.1,
AAC28869.1,
AAH11040.1,
AAA51624.1,
AAH57982.1,
AAM47488.1,
AAH49970.2
Ensembl_TRS:
ENSMUST00000078869,
ENSMUST00000085056
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000077909,
ENSMUSP00000082132
RefSeq:
NP_033272.1
|
| Others |
UniRef100:
UniRef100_P07758,
UniRef100_Q00897
UniRef90:
UniRef90_P22599
UniRef50:
UniRef50_P01009
UniGene:
Mm.439695
CCDS:
CCDS26139.1,
CCDS26140.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32723872 |
J Biol Chem Sergio Attanasio , Rosa Ferriero , Gwladys Gernoux , Rossella De Cegli , Annamaria Carissimo , Edoardo Nusco , Severo Campione , Jeffrey Teckman , Christian Mueller , Pasquale Piccolo , Nicola Brunetti-Pierri |
2020-09-18 | - |
| 31717526 |
Cells Nurdan Guldiken , Karim Hamesch , Shari Malan Schuller , Mahmoud Aly , Cecilia Lindhauer , Carolin V Schneider , Malin Fromme , Christian Trautwein , Pavel Strnad |
2019-11-09 | - |
| 30833329 |
J Biol Chem Nazli Khodayari , Regina Oshins , Abdel A Alli , Kubra M Tuna , L Shannon Holliday , Karina Krotova , Mark Brantly |
2019-04-19 | - |
| 24172014 |
Update of the human and mouse SERPIN gene superfamily. Hum. Genomics Claire Heit , Brian C Jackson , Monica McAndrews , Mathew W Wright , David C Thompson , Gary A Silverman , Daniel W Nebert , Vasilis Vasiliou |
2013-01-01 |
Agt,
Serpinb7,
Serpinc1,
Serping1,
Serpina6,
Serpind1,
Serpina3c,
Serpine1,
Serpinb2,
Serpinf2,
Serpinb3a,
Serpinf1,
Serpina1a,
Serpina1b,
Serpina1c,
Serpina1d,
Serpina1e,
Serpinb9b,
Serpinb9c,
Serpinb6b,
Serpinb9f,
Serpinb9e,
Serpini1,
Serpina3k,
Serpina3g,
Serpina3n,
Serpina3m,
Serpinb6a,
Serpine2,
Serpinb9,
Serpinb5,
Serpinb8,
Serpinb9d,
Serpina10,
Serpina3f,
Serpina3j,
Serpinb6d,
Serpinb13,
Serpinb10,
Serpina5,
Serpina3b,
Serpinb1b,
Serpinb1-ps1,
Serpine3,
Serpina4-ps1,
Serpina7,
Serpina11,
Serpinb1c,
Serpinb3c,
Serpinb3b,
Serpinb3d,
Serpina3d-ps,
Serpinb6e,
Serpina3h,
Serpina3e-ps,
Serpina3i,
Serpina3l-ps,
Serpinb1a,
Serpinb11,
Serpini2,
Serpina12,
Serpina1f,
Serpinb12,
Serpina9,
Serpina3a,
Serpinb9g,
Serpinb6c,
SERPINA7P1,
SERPINA15P,
SERPINE4P,
SERPINB8P1,
SERPINA3,
SERPINA12,
SERPINH1P1,
AGT,
SERPINB1,
SERPINB9P1,
SERPINA11,
SERPIND1,
SERPINA9,
SERPINA13P,
SERPINA2,
SERPINC1,
SERPINE1,
SERPINB2,
SERPINA5,
SERPINA10,
SERPINF1,
SERPINA1,
SERPINA4,
SERPINB5,
SERPINB6,
SERPINE2,
SERPINB8,
SERPINB9,
SERPINB10,
SERPINI1,
SERPINB13,
SERPINI2
|
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 21267068 |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. Graciana Diez-Roux , Sandro Banfi , Marc Sultan , Lars Geffers , Santosh Anand , David Rozado , Alon Magen , Elena Canidio , Massimiliano Pagani , Ivana Peluso , Nathalie Lin-Marq , Muriel Koch , Marchesa Bilio , Immacolata Cantiello , Roberta Verde , Cristian De Masi , Salvatore A Bianchi , Juliette Cicchini , Elodie Perroud , Shprese Mehmeti , Emilie Dagand , Sabine Schrinner , Asja Nürnberger , Katja Schmidt , Katja Metz , Christina Zwingmann , Norbert Brieske , Cindy Springer , Ana Martinez Hernandez , Sarah Herzog , Frauke Grabbe , Cornelia Sieverding , Barbara Fischer , Kathrin Schrader , Maren Brockmeyer , Sarah Dettmer , Christin Helbig , Violaine Alunni , Marie-Annick Battaini , Carole Mura , Charlotte N Henrichsen , Raquel Garcia-Lopez , Diego Echevarria , Eduardo Puelles , Elena Garcia-Calero , Stefan Kruse , Markus Uhr , Christine Kauck , Guangjie Feng , Nestor Milyaev , Chuang Kee Ong , Lalit Kumar , MeiSze Lam , Colin A Semple , Attila Gyenesei , Stefan Mundlos , Uwe Radelof , Hans Lehrach , Paolo Sarmientos , Alexandre Reymond , Duncan R Davidson , Pascal Dollé , Stylianos E Antonarakis , Marie-Laure Yaspo , Salvador Martinez , Richard A Baldock , Gregor Eichele , Andrea Ballabio |
2011-01-18 | - |
| 16141072 |
The transcriptional landscape of the mammalian genome. Science P Carninci , T Kasukawa , S Katayama , J Gough , M C Frith , N Maeda , R Oyama , T Ravasi , B Lenhard , C Wells , R Kodzius , K Shimokawa , V B Bajic , S E Brenner , S Batalov , A R R Forrest , M Zavolan , M J Davis , L G Wilming , V Aidinis , J E Allen , A Ambesi-Impiombato , R Apweiler , R N Aturaliya , T L Bailey , M Bansal , L Baxter , K W Beisel , T Bersano , H Bono , A M Chalk , K P Chiu , V Choudhary , A Christoffels , D R Clutterbuck , M L Crowe , E Dalla , B P Dalrymple , B de Bono , G Della Gatta , D di Bernardo , T Down , P Engstrom , M Fagiolini , G Faulkner , C F Fletcher , T Fukushima , M Furuno , S Futaki , M Gariboldi , P Georgii-Hemming , T R Gingeras , T Gojobori , R E Green , S Gustincich , M Harbers , Y Hayashi , T K Hensch , N Hirokawa , D Hill , L Huminiecki , M Iacono , K Ikeo , A Iwama , T Ishikawa , M Jakt , A Kanapin , M Katoh , Y Kawasawa , J Kelso , H Kitamura , H Kitano , G Kollias , S P T Krishnan , A Kruger , S K Kummerfeld , I V Kurochkin , L F Lareau , D Lazarevic , L Lipovich , J Liu , S Liuni , S McWilliam , M Madan Babu , M Madera , L Marchionni , H Matsuda , S Matsuzawa , H Miki , F Mignone , S Miyake , K Morris , S Mottagui-Tabar , N Mulder , N Nakano , H Nakauchi , P Ng , R Nilsson , S Nishiguchi , S Nishikawa , F Nori , O Ohara , Y Okazaki , V Orlando , K C Pang , W J Pavan , G Pavesi , G Pesole , N Petrovsky , S Piazza , J Reed , J F Reid , B Z Ring , M Ringwald , B Rost , Y Ruan , S L Salzberg , A Sandelin , C Schneider , C Schönbach , K Sekiguchi , C A M Semple , S Seno , L Sessa , Y Sheng , Y Shibata , H Shimada , K Shimada , D Silva , B Sinclair , S Sperling , E Stupka , K Sugiura , R Sultana , Y Takenaka , K Taki , K Tammoja , S L Tan , S Tang , M S Taylor , J Tegner , S A Teichmann , H R Ueda , E van Nimwegen , R Verardo , C L Wei , K Yagi , H Yamanishi , E Zabarovsky , S Zhu , A Zimmer , W Hide , C Bult , S M Grimmond , R D Teasdale , E T Liu , V Brusic , J Quackenbush , C Wahlestedt , J S Mattick , D A Hume , C Kai , D Sasaki , Y Tomaru , S Fukuda , M Kanamori-Katayama , M Suzuki , J Aoki , T Arakawa , J Iida , K Imamura , M Itoh , T Kato , H Kawaji , N Kawagashira , T Kawashima , M Kojima , S Kondo , H Konno , K Nakano , N Ninomiya , T Nishio , M Okada , C Plessy , K Shibata , T Shiraki , S Suzuki , M Tagami , K Waki , A Watahiki , Y Okamura-Oho , H Suzuki , J Kawai , Y Hayashizaki , FANTOM Consortium , RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) |
2005-09-02 | - |
| 16141073 |
Antisense transcription in the mammalian transcriptome. Science S Katayama , Y Tomaru , T Kasukawa , K Waki , M Nakanishi , M Nakamura , H Nishida , C C Yap , M Suzuki , J Kawai , H Suzuki , P Carninci , Y Hayashizaki , C Wells , M Frith , T Ravasi , K C Pang , J Hallinan , J Mattick , D A Hume , L Lipovich , S Batalov , P G Engström , Y Mizuno , M A Faghihi , A Sandelin , A M Chalk , S Mottagui-Tabar , Z Liang , B Lenhard , C Wahlestedt , RIKEN Genome Exploration Research Group , Genome Science Group (Genome Network Project Core Group) , FANTOM Consortium |
2005-09-02 |
Gm14018,
Gm14964,
F630206G17Rik,
Oog3,
Notumos,
Ldlrap1,
Mdn1,
Pydc3,
9330171B17Rik,
Mfap1b,
Tmsb15b2,
Gm12802,
E430020m11rik,
Gm11335,
Gm15772,
Gm17762,
A930017K11Rik,
LOC100036513,
Gata5os,
Umad1,
Gm16982,
Gm9887,
Gm9872,
LOC100036530,
Gm9934,
Gm9913,
Gm11149,
BC028777,
Gm13999,
LOC100036540,
Gm9744,
Gm9983,
D630002J18Rik,
Gm16525,
Gm11696,
Dnajc3,
9430060I03Rik,
Gm12359,
4921516A02Rik,
Fam129c,
Gm10589,
Rsph3b,
Rnaset2a,
5430403G19Rik,
D030047H15Rik,
Gm13274,
B930046K06Rik,
Gm10862,
Gm10792,
Gm10802,
Gm10532,
G730003C15Rik,
Runx2os1,
Gm15612,
Gm10856,
Gm10857,
Gm10685,
Gm10803,
Gm10723,
F630028O10Rik,
Gm10836,
Gm10405,
Gm10513,
Gm10609,
F630201L12Rik,
4932427H20Rik,
Zfp389,
Gm10763,
Gm10062,
Gm10714,
Gm10531,
Gm10876,
Gm10750,
Gm10433,
Gm10837,
Gm10647,
Gm10648,
Gm10650,
Gm10610,
F830115B05Rik,
Gm10473,
Gm10614,
Gm10286,
G730046D07Rik,
Gm10287,
Gm10785,
Gm10183,
Gm10512,
1700061E17Rik,
Gm44113,
Gm10579,
Gm10741,
Gm10827,
Gm10522,
Gm10536,
Gm15998,
Faddos,
D130050E23Rik,
Gm10735
|
| 15795238 |
J. Exp. Med. Ingrid G Winkler , Jean Hendy , Paul Coughlin , Anita Horvath , Jean-Pierre Lévesque |
2005-04-04 | - |
| 12659817 |
Genomics Sharon Forsyth , Anita Horvath , Paul Coughlin |
2003-03-01 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员