| Type | Description |
|---|---|
| Definition | trans-acting transcription factor 4 |
| Date | Results | Publications |
|---|---|---|
| 2019-11-02 12:47:00 | Although our studies initially focused on the relationship between Sp4, TRPV1 and thermal hyperalgesia, our results more broadly suggest that a larger Sp4-dependent gene network or nociceptive transcriptome exists inclusive of TRPV1, TRPA1 and TRPM8. | 30811405 |
| 2019-08-03 10:11:00 | depletion of Sp4 and Klf5 decreased Tas1r1 expression, while overexpression of Klf5, but not Sp4, significantly increased Tas1r1 expression in the myoblast cells. | 30982802 |
| 2018-06-30 10:54:00 | Sp4 hypomorphic mice had markedly elevated theta power localized frontally and parietally, a more pronounced theta phase progression along the neuraxis, and a stronger frontal-parietal theta coupling. Acute subanesthetic ketamine did not affect theta power in wildtype animals but significantly reduced it in Sp4 hypomorphic mice, nearly completely neutralizing their excessive frontal/parietal theta power. | 29513708 |
| 2017-10-14 10:38:00 | elucidation of the Sp4 molecular pathway in Sp4 hypomorphic mice may provide novel insights to our understanding of abnormal NMDAR signaling in schizophrenia | 23823008 |
| 2016-08-06 11:06:00 | The transcription factor Specificity Protein 4 (SP4) is important for neurodevelopment and is genetically associated with both schizophrenia and bipolar disorder. | 25907107 |
| Type | IDs |
|---|---|
| Synonymous | 5730497N03Rik, HF-1b, HF1-b |
| Gene |
UniProtKB-ID:
K4DI62_MOUSE,
Q6DFV2_MOUSE,
A0A1Y7VJR5_MOUSE
UniprotKB:
K4DI62,
Q6DFV2,
A0A1Y7VJR5
UniParc:
UPI0003D3CDEB,
UPI00003BF2D5,
UPI000274725A
EMBL:
AC163032,
AC163034,
BC076630
Ensembl:
ENSMUSG00000025323
KO:
mmu:20688
|
| Nucleutide sequences |
EMBL-CDS:
AAH76630.1
Ensembl_TRS:
ENSMUST00000026367,
ENSMUST00000222314
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000026367,
ENSMUSP00000152603
RefSeq:
NP_033265.4,
XP_036013171.1,
XP_017170496.1,
NP_001159857.2,
XP_036013172.1
|
| Others |
UniRef100:
UniRef100_A0A1Y7VJR5,
UniRef100_Q6DFV2,
UniRef100_K4DI62
UniRef90:
UniRef90_Q62445
UniRef50:
UniRef50_Q62445
UniGene:
Mm.259312
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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