| Type | Description |
|---|---|
| Definition | SOS Ras/Rho guanine nucleotide exchange factor 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-10-12 11:11:00 | Results indicat son of sevenless homolog 2 protein (SOS2) critically mediated mutant KRAS-driven, but not HRAS-driven, transformation. | 30181243 |
| 2019-06-22 11:22:00 | Our data unveil novel, distinctive mechanistic roles of Sos 1 and Sos2 in physiological control of skin homeostasis and wound repair, as well as in pathological development of chemically induced skin tumors. | 29844066 |
| 2015-10-31 10:25:00 | The increased activity of the PI3K/AKT pathway led to downregulation of the surface receptor CD62L in Sos-1/2dKO T cells and a subsequent impairment in T-cell migration. | 25973715 |
| 2013-12-28 10:34:00 | Absolute counts of mature B and T cells in spleen and peripheral blood were unchanged in single-knockout mutants, while significantly reduced in Sos1/2 double-knockout mice. | 24043312 |
| 2012-09-22 10:22:00 | assessed the independent and combined roles for the RasGEFs Sos1, Sos2, and RasGRP1 during thymocyte development | 22586275 |
| Type | IDs |
|---|---|
| Synonymous | SOS-2, mSOS-2 |
| Gene |
UniProtKB-ID:
SOS2_MOUSE,
A0A0A0MQ87_MOUSE
UniprotKB:
Q02384,
A0A0A0MQ87
UniParc:
UPI000035435D,
UPI00001E2E4B
EMBL:
AC133949,
AC141560,
AC153658,
Z11664
Ensembl:
ENSMUSG00000034801
KO:
mmu:20663
|
| Nucleutide sequences |
EMBL-CDS:
CAA77732.1
Ensembl_TRS:
ENSMUST00000183277,
ENSMUST00000035773
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000138793,
ENSMUSP00000044866
RefSeq:
NP_001129031.1,
XP_006515698.1
|
| Others |
UniRef100:
UniRef100_A0A0A0MQ87,
UniRef100_Q02384
UniRef90:
UniRef90_Q07890
UniRef50:
UniRef50_Q07890
UniGene:
Mm.3770
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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