| Type | Description |
|---|---|
| Definition | SOS Ras/Rac guanine nucleotide exchange factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-07-20 10:28:00 | Unique dependence on Sos1 in Kras (G12D) -induced leukemogenesis. | 30377195 |
| 2019-06-22 11:22:00 | Sos1 disruption delayed the onset of tumor initiation, decreased tumor growth, and prevented malignant progression of papillomas in a DMBA (7,12-dimethylbenz[alpha]anthracene)/TPA (12-O-tetradecanoylphorbol-13-acetate)-induced skin carcinogenesis model. | 29844066 |
| 2017-09-02 10:07:00 | a direct mechanistic link between Sos1 and control of intracellular oxidative stress, and demonstrate functional prevalence of Sos1 over Sos2 with regards to cellular proliferation and viability. | 27157612 |
| 2016-02-27 10:42:00 | findings suggest that targeting the Src/Abl/Sos1/Rac pathway may represent a double-edged sword to control both cancer-invasive capacities and cancer-related inflammation. | 26447228 |
| 2015-10-31 10:25:00 | The increased activity of the PI3K/AKT pathway led to downregulation of the surface receptor CD62L in Sos-1/2dKO T cells and a subsequent impairment in T-cell migration. | 25973715 |
| Type | IDs |
|---|---|
| Synonymous | 4430401P03Rik, 9630010N06, AI449023 |
| Gene |
UniProtKB-ID:
SOS1_MOUSE,
Q3USK4_MOUSE
UniprotKB:
Q62245,
Q3USK4
UniParc:
UPI00005ABF9C,
UPI0000028B8E
EMBL:
Z11574,
Z11578,
AK140310
Ensembl:
ENSMUSG00000024241
KO:
mmu:20662
|
| Nucleutide sequences |
EMBL-CDS:
CAA77665.1,
CAA77662.1,
BAE24327.1
Ensembl_TRS:
ENSMUST00000068714
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000067786
RefSeq:
NP_033257.2,
XP_036016318.1
|
| Others |
UniRef100:
UniRef100_Q3USK4,
UniRef100_Q62245
UniRef90:
UniRef90_Q62245
UniRef50:
UniRef50_Q07889
UniGene:
Mm.60975,
Mm.360004
CCDS:
CCDS37704.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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