| Type | Description |
|---|---|
| Definition | sortilin-related receptor, LDLR class A repeats-containing |
| Date | Results | Publications |
|---|---|---|
| 2021-01-02 12:51:00 | Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis. | 32601248 |
| 2020-02-22 13:04:00 | SorCS1 and SorLA expression were markedly reduced in the frontal cerebral cortex and to a minor extent in the hippocampus, whereas SorCS3 expression was solely reduced in the frontal cerebral cortex | 31095505 |
| 2017-12-23 11:01:00 | These results demonstrate a novel role for SORLA as a physiological and pathological EphA4 modulator. | 29114064 |
| 2017-12-02 11:05:00 | Results demonstrate that the lack of SORLA results in accumulation of phosphorylated synapsins in cortex and hippocampus. Authors propose an underlying molecular mechanism by demonstrating that SORLA interacts with phosphorylated synapsins through 14-3-3 adaptor proteins to deliver synapsins to calpain-mediated proteolytic degradation. | 27021222 |
| 2017-09-30 10:40:00 | Analysis of the molecular mechanism for the association of SORL1 with obesity: there is a genetic link between neurodegeneration and metabolism that converges on the receptor SORLA | 27322061 |
| Type | IDs |
|---|---|
| Synonymous | 2900010L19Rik, AI596264, AW261561, LR11, SorLA, gp250, mSorLA |
| Gene |
UniProtKB-ID:
SORL_MOUSE
UniprotKB:
O88307
UniParc:
UPI000047B0FA
EMBL:
AK147303,
AF031816,
Y12004,
AB015790
Ensembl:
ENSMUSG00000049313
KO:
mmu:20660
|
| Nucleutide sequences |
EMBL-CDS:
AAC16739.1,
BAE27834.1,
BAA31219.1,
CAA72732.1
Ensembl_TRS:
ENSMUST00000060989
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000058613
RefSeq:
NP_001344190.1,
NP_035566.2
|
| Others |
UniRef100:
UniRef100_O88307
UniRef90:
UniRef90_O88307
UniRef50:
UniRef50_Q92673
UniGene:
Mm.121920
CCDS:
CCDS40594.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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