| Type | Description |
|---|---|
| Definition | epidermal growth factor receptor pathway substrate 8 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-19 13:39:00 | miR-345 inhibits migration and stem-like cell phenotype in gastric cancer via inactivation of Rac1 by targeting EPS8. | 32147678 |
| 2020-01-25 11:47:00 | LncRNA DSCAM-AS1 acts as a competing endogenous RNA of miR-137 and regulates EPS8 to promote cell reproduction and suppresses cell apoptosis in Tamoxifen-resistant breast cancer | 30203615 |
| 2019-12-21 11:06:00 | We identified EE02 as an EGFR/Eps8 complex inhibitor that demonstrated promising antitumor effects in breast cancer and non-small cell lung cancer (NSCLC). Our data suggest that the EGFR/Eps8 complex offers a novel cancer drug target. | 31118055 |
| 2019-09-07 11:24:00 | we focused on EPS8 because its expression had the greatest impact on patient prognosis (overall survival, p < 0.0001). Overexpression of EPS8 was detected in PDAC clinical specimens. Knockdown assays with siEPS8 showed that its overexpression enhanced cancer cell proliferation, migration, and invasion | 30858505 |
| 2019-02-09 10:55:00 | Eps8 is involved in tumor invasion but not necessarily the development of regional lymph node metastasis | 29107665 |
| Type | IDs |
|---|---|
| Synonymous | DFNB102 |
| Gene |
UniProtKB-ID:
EPS8_HUMAN,
B4E3T6_HUMAN
UniprotKB:
Q12929,
B4E3T6
UniParc:
UPI00017A8921,
UPI0000E5950C,
UPI000012A0BC
EMBL:
U12535,
AK301834,
AC092753,
BC030010,
AC073651,
AC022073,
AK292931,
CH471094,
AK316134,
AK291777,
AK316239,
AK304860
Ensembl:
ENSG00000151491
KO:
hsa:2059
|
| Nucleutide sequences |
EMBL-CDS:
AAH30010.1,
BAH14610.1,
BAF85620.1,
EAW96355.1,
EAW96354.1,
BAH14505.1,
BAF84466.1,
BAG63278.1,
AAA62280.1,
BAG65598.1
Ensembl_TRS:
ENST00000543612,
ENST00000542903,
ENST00000646918,
ENST00000642278,
ENST00000646828,
ENST00000647224,
ENST00000644374,
ENST00000645775,
ENST00000543523,
ENST00000647087,
ENST00000281172,
ENST00000540613
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000495824,
ENSP00000441888,
ENSP00000494842,
ENSP00000441867,
ENSP00000495722,
ENSP00000437806,
ENSP00000495956,
ENSP00000442388,
ENSP00000496406,
ENSP00000281172,
ENSP00000494689,
ENSP00000496516
RefSeq:
XP_024304646.1,
XP_024304648.1,
XP_024304649.1,
XP_011518907.1,
XP_024304650.1,
XP_024304647.1,
NP_004438.3
|
| Others |
UniRef100:
UniRef100_Q12929,
UniRef100_B4E3T6
UniRef90:
UniRef90_I3LP99,
UniRef90_Q12929
UniRef50:
UniRef50_Q5R4H4,
UniRef50_Q08509
UniGene:
Hs.591160
CCDS:
CCDS31753.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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