| Type | Description |
|---|---|
| Definition | solute carrier family 22 (organic cation transporter), member 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-18 11:00:00 | Dystrophin deficiency likely disrupts Octn2 expression decreasing muscle carnitine uptake thus contributing to membranotoxic long-chain acyl-CoAs with sarcolemmal and organellar membrane oxidative injury | 32070725 |
| 2019-09-14 10:42:00 | l-carnitine deficiency due to a defect in the carnitine transporter OCTN2 (SLC22A5) in a mouse model leads to embryonic lethality. Placental levels of l-carnitine are reduced to <10% of normal and deficiency of l-carnitine is associated with markedly reduced expression of several growth factors and transforming growth factor beta (TGF-beta) genes. | 30213487 |
| 2019-07-20 10:17:00 | Acute and chronic administration of clozapine to mice resulted in 2-3-fold greater renal excretion of L-carnitine (L-Car) than in the vehicle group. Concomitantly, mRNA and protein levels of mOctn2 in the kidney were markedly down regulated. These results indicate that clozapine-induced reduction of L-Car reabsorption via inhibition/down-regulation of renal Octn2 contributes to liver lipid metabolic disorder. | 30465787 |
| 2018-06-30 12:04:00 | Both mRNA and protein levels of OCTN2 were detected in kidney after exercise and during recovery, suggesting renal transport mechanisms were stimulated. These changes were accompanied with a reciprocal increase in PPARalpha protein expression. | 28668962 |
| 2013-04-27 12:09:00 | There was increased apoptosis in gut samples from OCTN2(-/-) mice. | 23112839 |
| Type | IDs |
|---|---|
| Synonymous | Lstpl, Octn2, jvs |
| Gene |
UniProtKB-ID:
S22A5_MOUSE,
Q5SX17_MOUSE
UniprotKB:
Q9Z0E8,
Q5SX17
UniParc:
UPI0000001A84
EMBL:
AF110417,
AK167451,
AF111425,
AB015800,
BC031118
Ensembl:
ENSMUSG00000018900
KO:
mmu:20520
|
| Nucleutide sequences |
EMBL-CDS:
AAH31118.1,
AAC99787.1,
BAA36590.1,
AAD54060.1,
BAE39537.1
Ensembl_TRS:
ENSMUST00000019044
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000019044
RefSeq:
XP_036012373.1,
XP_006532713.1,
NP_001349640.1,
XP_036012372.1,
NP_001349641.1,
XP_006532714.1,
NP_035526.1
|
| Others |
UniRef100:
UniRef100_Q9Z0E8
UniRef90:
UniRef90_Q9Z0E8
UniRef50:
UniRef50_O76082
UniGene:
Mm.42253
CCDS:
CCDS24687.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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