| Type | Description |
|---|---|
| Definition | solute carrier family 22 (organic cation transporter), member 3 |
| Date | Results | Publications |
|---|---|---|
| 2018-03-10 10:52:00 | Study is the first to examine the subcellular localization of organic cation transporter 3 (OCT3) in any tissue, and the first to explore its spatial relationship to synaptic structures in the brain. Study suggests that OCT3 not only contributes to the clearance of extracellular monoamines, but also plays a role in their intracellular disposition and action. | 27659446 |
| 2017-03-04 11:08:00 | Metformin undergoes negligible metabolism, these results imply that intestinal absorption of metformin is mediated at least in part by Oct3 in mice. | 27569291 |
| 2016-04-23 11:55:00 | Study showed that few, if any, 5-HT neurons in the dorsal raphe are resistant to loss of Pet-1 for expression of Slc22a3 | 25642596 |
| 2015-08-15 11:14:00 | Findings suggest that OCT3 plays an important role in the absorption and elimination of metformin and that the transporter is a critical determinant of metformin bioavailability, clearance, and pharmacologic action. | 25920679 |
| 2014-12-20 13:08:00 | These results demonstrate that OCT3 is responsible for metformin accumulation and secretion in salivary glands. | 25107910 |
| Type | IDs |
|---|---|
| Synonymous | EMT, Oct3, Orct3, Slca22a3 |
| Gene |
UniProtKB-ID:
S22A3_MOUSE,
Q547K2_MOUSE
UniprotKB:
Q9WTW5,
Q547K2
UniParc:
UPI00000011F7
EMBL:
BC137661,
AF078748,
AF082566,
AF078750,
BC137662,
AK143988,
AF481053
Ensembl:
ENSMUSG00000023828
KO:
mmu:20519
|
| Nucleutide sequences |
EMBL-CDS:
AAD53007.1,
AAD20238.1,
AAD20978.1,
AAM22155.1,
BAE25648.1,
AAI37662.1,
AAI37663.1
Ensembl_TRS:
ENSMUST00000024595
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000024595
RefSeq:
NP_035525.1
|
| Others |
UniRef100:
UniRef100_Q9WTW5
UniRef90:
UniRef90_Q9WTW5
UniRef50:
UniRef50_Q9WTW5
UniGene:
Mm.99252
CCDS:
CCDS28391.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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