| Type | Description |
|---|---|
| Definition | solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-07 10:50:00 | EAAT4 role in the spontaneous firing pattern and survival of Purkinje cells. | 29741614 |
| 2019-09-21 12:52:00 | Reduced Cerebellar EAAT4 Expression associated with loss of cerebellar Purkinje cells resluts in neurodegeneration and Niemann-Pick disease Type C1. | 29463856 |
| 2019-01-26 11:16:00 | Overexpressed miR-128 downregulates the expression of AXIN1 but upregulates that of EAAT4 in dopamine neurons of Parkinson's disease mice. | 30537735 |
| 2018-03-03 11:48:00 | Loss of EAAT4 accounts for the initial hyper-excitability of Purkinje cells lacking b-III spectrin and that loss of GLAST appears to work synergistically to worsen motor deficits. When levels of both EAAT4 and GLAST are compromised in b-III(-/-) mice, the proximal dendrites of Purkinje cells within the posterior cerebellum are the most vulnerable to degeneration. | 28173092 |
| 2017-03-11 12:11:00 | EAAT4 was downregulated due to the loss of Rheb1 in Purkinje cells; mTORC1 was downregulated and Akt was upregulated in Rheb1 cKO mice, suggesting that mTORC1 and Akt may be related to the downregulation of EAAT4; Rheb1 knockout decreased EAAT4 currents and slowed down the kinetics of AMPA currents; Rheb1 deficiency did not affect the morphology of Purkinje cell layer and the development of Purkinje cells | 26194056 |
| Type | IDs |
|---|---|
| Synonymous | EAAT4 |
| Gene |
UniProtKB-ID:
EAA4_MOUSE,
Q3TXM3_MOUSE,
B2RQX4_MOUSE
UniprotKB:
O35544,
Q3TXM3,
B2RQX4
UniParc:
UPI0000020E9E,
UPI00005AD296
EMBL:
AK159197,
BC138140,
BC138120,
D83262
Ensembl:
ENSMUSG00000005357
KO:
mmu:20513
|
| Nucleutide sequences |
EMBL-CDS:
BAA23640.1,
BAE34892.1,
AAI38141.1,
AAI38121.1
Ensembl_TRS:
ENSMUST00000005490
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000005490
RefSeq:
XP_030100832.1,
XP_006513487.1,
XP_036011608.1,
XP_006513485.3,
NP_033226.1
|
| Others |
UniRef100:
UniRef100_Q3TXM3,
UniRef100_O35544
UniRef90:
UniRef90_O35544
UniRef50:
UniRef50_P48664
UniGene:
Mm.6257
CCDS:
CCDS23970.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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