| Type | Description |
|---|---|
| Definition | siah E3 ubiquitin protein ligase 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-28 13:16:00 | Siah2 integrates mitogenic and extracellular matrix signals linking neuronal progenitor ciliogenesis with germinal zone occupancy. | 33082319 |
| 2020-11-21 13:26:00 | SIAH2-mediated and organ-specific restriction of HO-1 expression by a dual mechanism. | 32042051 |
| 2020-04-25 11:34:00 | Growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2(-/-) mice. | 31911617 |
| 2020-01-11 10:54:00 | The stimulation of thermogenic gene and protein expression and regulation of ERalpha and ERRgamma protein levels only in the Siah2-deficient females suggests that Siah2 restrains the impact of ERalpha and ERRgamma proteins on brown fat function in females, but not in male mice. This finding further underscores the sex-dependent roles of Siah2 in key metabolic tissues when challenged with chronic excess calorie intake. | 30987673 |
| 2018-01-06 10:46:00 | The results suggest that SIAH2 plays a pivotal role to promote Th17 cell differentiation through maintaining the stability of HIF-1alpha protein. | 28338984 |
| Type | IDs |
|---|---|
| Synonymous | AA415433, Sinh2 |
| Gene |
UniProtKB-ID:
SIAH2_MOUSE,
Q3UEV2_MOUSE
UniprotKB:
Q06986,
Q3UEV2
UniParc:
UPI00001D6876
EMBL:
BC058400,
AK149316,
Z19581
Ensembl:
ENSMUSG00000036432
KO:
mmu:20439
|
| Nucleutide sequences |
EMBL-CDS:
CAA79632.1,
AAH58400.1,
BAE28809.1
Ensembl_TRS:
ENSMUST00000070368
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000067496
RefSeq:
NP_033200.2
|
| Others |
UniRef100:
UniRef100_Q06986
UniRef90:
UniRef90_Q06986
UniRef50:
UniRef50_O43255
UniGene:
Mm.2847
CCDS:
CCDS17368.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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