| Type | Description |
|---|---|
| Definition | SH2B adaptor protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-25 13:01:00 | Mice with LepR neuron-specific or adult-onset, hypothalamus-specific ablation of Sh2b1 develop obesity, insulin resistance, and liver steatosis. Hypothalamic overexpression of human SH2B1 protects against high fat diet-induced obesity and metabolic syndromes. Results unravel an unrecognized LepR neuron Sh2b1/ sympathetic nervous system/brown adipose tissue /thermogenesis axis that combats obesity and metabolic disease. | 32251290 |
| 2019-09-07 10:12:00 | The increased expression of genes in leptin or AKT) signaling implies that the main mode of action for SH2B1 mutations might affect leptin signaling rather than insulin signaling. | 29631267 |
| 2018-12-22 11:27:00 | Brain-specific Sh2b1 knockout (KO) mice exhibited brain growth retardation and reactive aggression. | 29180441 |
| 2017-06-10 12:02:00 | data identify SH2B1 as a major regulator of IRS2 stability, demonstrate a novel feedback mechanism linking mTORC1 signaling with IRS2, and identify 4E-BP2 as a major regulator of proliferation and survival of beta-cells. | 27217487 |
| 2016-05-07 11:08:00 | that SH2B1 is a key positive mediator of pathological cardiac hypertrophy | 26077624 |
| Type | IDs |
|---|---|
| Synonymous | AI425885, C530001K22Rik, Irip, Psm, SH2-B, SH2-Bb, Sh2bpsm1, mKIAA1299 |
| Gene |
UniProtKB-ID:
SH2B1_MOUSE
UniprotKB:
Q91ZM2
UniParc:
UPI000166305A,
UPI00000298A3,
UPI000002984C,
UPI0000028104,
UPI0001663059,
UPI000002984D
EMBL:
AK168439,
BC011422,
AK170444,
AF020526,
BC051978,
AF380422,
AF421138,
AF036355,
AF074329,
AF421139
Ensembl:
ENSMUSG00000030733
KO:
mmu:20399
|
| Nucleutide sequences |
EMBL-CDS:
AAH11422.1,
AAC33414.1,
BAE40344.1,
BAE41802.1,
AAH51978.1,
AAL07566.1,
AAL16069.1,
AAC39955.2,
AAD41655.1,
AAL16070.1
Ensembl_TRS:
ENSMUST00000205889,
ENSMUST00000205733,
ENSMUST00000205340,
ENSMUST00000205497,
ENSMUST00000032978,
ENSMUST00000206664,
ENSMUST00000205440
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000032978,
ENSMUSP00000145554,
ENSMUSP00000145953,
ENSMUSP00000146282,
ENSMUSP00000145842,
ENSMUSP00000145754,
ENSMUSP00000146121
RefSeq:
XP_030098120.1,
NP_001276469.1,
NP_001276468.1,
XP_030098121.1,
XP_006507545.1,
NP_001276471.1,
XP_006507543.1,
NP_001276467.1,
NP_001074928.1,
XP_006507548.1,
XP_006507544.1,
XP_006507550.1,
XP_006507541.1,
NP_035493.2,
NP_001276470.1
|
| Others |
UniRef100:
UniRef100_Q91ZM2
UniRef90:
UniRef90_Q62985
UniRef50:
UniRef50_Q62985
UniGene:
Mm.8538
CCDS:
CCDS85410.1,
CCDS40126.1,
CCDS85411.1,
CCDS85412.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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