| Type | Description |
|---|---|
| Definition | sphingosine phosphate lyase 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:12:00 | Suppression of sphingosine 1-phosphate lyase retards the liver regeneration in mice after partial hepatectomy. | 32614038 |
| 2021-01-02 12:51:00 | Sphingosine 1-phosphate lyase blockade elicits myogenic differentiation of murine myoblasts acting via Spns2/S1P2 receptor axis. | 32565314 |
| 2020-12-26 13:11:00 | S1P-lyase deficiency uncouples ganglioside formation - Potential contribution to tumorigenic capacity. | 32283310 |
| 2020-03-21 12:40:00 | Study identified S1P receptor 2 (S1PR2) as the mediator of both impaired autophagy and proinflammatory effects. The addition of exogenous S1P to BV2 microglial cells showed similar effects as those observed in the genetic knock out of SGPL1 in neural cells. Results show a novel role of the S1P-S1PR2 axis in the microglia of mice with neural-targeted SGPL1 ablation and in BV2 microglial cells exogenously treated with S1P. | 31231866 |
| 2020-03-14 11:45:00 | S1P is a potent osteoanabolic molecule, although S1P3 is not the sole receptor mediating this influence | 31314788 |
| Type | IDs |
|---|---|
| Synonymous | AI428538, D10Xrf456, S1PL, Spl |
| Gene |
UniProtKB-ID:
SGPL1_MOUSE
UniprotKB:
Q8R0X7
UniParc:
UPI0000027D15
EMBL:
AF036894,
AK037789,
BC026135,
AK049342,
AK036747,
AK043024
Ensembl:
ENSMUSG00000020097
KO:
mmu:20397
|
| Nucleutide sequences |
EMBL-CDS:
AAC03768.1,
BAC31437.1,
BAC29562.1,
BAC29872.1,
BAC33695.1,
AAH26135.1
Ensembl_TRS:
ENSMUST00000092498,
ENSMUST00000122259
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000112975,
ENSMUSP00000090155
RefSeq:
NP_033189.2,
XP_017169349.1,
NP_001303602.1,
XP_036011604.1,
NP_001303603.1
|
| Others |
UniRef100:
UniRef100_Q8R0X7
UniRef90:
UniRef90_Q8R0X7
UniRef50:
UniRef50_Q8R0X7
UniGene:
Mm.412319,
Mm.431862
CCDS:
CCDS35914.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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