| Type | Description |
|---|---|
| Definition | serine/arginine-rich splicing factor 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-07-20 11:24:00 | In a new conditional murine Srsf2(P95H) model, where the P95H mutation is expressed physiologically and heterozygously from its endogenous locus after Cre activation, the mutation must occur in the hemopoietic stem-cell-containing populations to promote myelomonocytic bias and expansion with transcriptional and RNA splicing changes. With age, nontransplanted mutant animals develop progressive, transplantablable disease. | 29903888 |
| 2019-02-09 11:58:00 | Mutant Srsf2 leads to a compromised Hematopoietic stem cell function by causing abnormal RNA splicing and expression, contributing to the deregulated hematopoiesis that recapitulates the Myelodysplastic syndromes phenotypes, possibly as a result of additional genetic and/or environmental insults. | 29146882 |
| 2017-09-16 12:33:00 | Posttranslational modification of SR proteins underlies the regulation of their mRNA export activities and distinguishes pluripotent from differentiated cells. | 28592444 |
| 2017-08-12 11:36:00 | Mice expressing Srsf2 mutation Srsf2P95H, which commonly occurs in individuals with MDS and AML, in an inducible, hemizygous manner in hematopoietic cells rapidly succumbed to fatal bone marrow failure, demonstrating that Srsf2-mutated cells depend on the wild-type Srsf2 allele for survival. | 27135740 |
| 2017-05-27 10:26:00 | Findings have shown that SRSF2 not only is involved in splicing regulation of a large number of transcripts but also activates transcription of metabolism-related genes and transcription factors. | 27022105 |
| Type | IDs |
|---|---|
| Synonymous | D11Wsu175e, MRF-1, Pr264, SC35, Sfrs10, Sfrs2 |
| Gene |
UniProtKB-ID:
SRSF2_MOUSE
UniprotKB:
Q62093
UniParc:
UPI0000000C2A
EMBL:
AF077858,
BC005493,
U14648,
AK086103,
AK165670,
X98511,
AK088042
Ensembl:
ENSMUSG00000034120
KO:
mmu:20382
|
| Nucleutide sequences |
EMBL-CDS:
BAC40111.1,
AAA64595.1,
BAC39610.1,
AAC71000.1,
BAE38330.1,
AAH05493.1,
CAA67134.1
Ensembl_TRS:
ENSMUST00000190993,
ENSMUST00000136914,
ENSMUST00000092404
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000140016,
ENSMUSP00000090059,
ENSMUSP00000120086
RefSeq:
XP_011247137.1,
NP_035488.1,
XP_030101584.1
|
| Others |
UniRef100:
UniRef100_Q01130
UniRef90:
UniRef90_Q01130
UniRef50:
UniRef50_Q01130
UniGene:
Mm.21841,
Mm.429312,
Mm.469331
CCDS:
CCDS25680.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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