| Type | Description |
|---|---|
| Definition | sodium channel, nonvoltage-gated 1 alpha |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 12:23:00 | Cell-specific EnNaC is important in propagating pulsatility into the renal circulation, generating oxidant stress, reduced bioavailable NO, and renal vessel wall fibrosis and stiffening. | 32281419 |
| 2020-06-20 11:15:00 | Estrogen treatment decreased alpha-ENaC expression but increased derlin-1 expression in mouse renal collecting duct (mpkCCDc14) cells. | 31113930 |
| 2020-05-09 10:17:00 | Epithelial Na(+) channel's (ENaC) able to mediate shear force responsiveness relies on the "force-from-filament" principle involving extracellular tethers and the extracellular matrix. Two glycosylated asparagines, respectively their N-glycans localized in the palm and knuckle domains of alphaENaC, were identified as potential tethers. Endothelial-specific overexpression of alphaENaC in mice induced hypertension. | 31871197 |
| 2020-04-11 12:29:00 | Autosomal dominant polycystic kidney disease cysts epithelia exhibit a hyperexpression of pannexin-1 and P2X7 proteins. Pannexin-1 in renal epithelial cells mediates ATP release into the lumen. P2X7 activation shown earlier to facilitate Panx1 conductance, reduces ENaC activity. | 30952430 |
| 2020-01-11 12:14:00 | This study demonstrates that CLDN7 plays an important role in salt balance in renal CD cells and modulating WNK4 and ENaC expression levels that are vital in controlling salt-sensitive hypertension. | 31382627 |
| Type | IDs |
|---|---|
| Synonymous | ENaC, SCNEA, Scnn1, mENaC |
| Gene |
UniProtKB-ID:
SCNNA_MOUSE,
Q3USG4_MOUSE
UniprotKB:
Q61180,
Q3USG4
UniParc:
UPI0000027EDC,
UPI00005ABFB2
EMBL:
BC133688,
AK140389,
U52006,
BC133689,
AF112185,
AC140324
Ensembl:
ENSMUSG00000030340
KO:
mmu:20276
|
| Nucleutide sequences |
EMBL-CDS:
AAD21244.1,
AAA97412.1,
AAI33690.1,
AAI33689.1,
BAE24368.1
Ensembl_TRS:
ENSMUST00000081440
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000080164
RefSeq:
XP_036021864.1,
NP_035454.2,
XP_017176960.1,
XP_030111136.1
|
| Others |
UniRef100:
UniRef100_Q61180
UniRef90:
UniRef90_Q61180
UniRef50:
UniRef50_P37089
UniGene:
Mm.144114
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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